Microarray Analysis of Serum mRNA in Patients with Head and Neck Squamous Cell Carcinoma at Whole-Genome Scale
Table 2
SPIA comparison of cancer serum specimens and healthy individuals serum specimens shows significant upregulation of pathways involved in antigen processing and presentation, focal adhesion, viral carcinogenesis, regulation of actin cytoskeleton, and downregulation of pathways involved in RNA transport, leukocyte transendothelial migration, natural-killer-cell-mediated cytotoxicity, and pathways connected with some neurodegenerative or autoimmune diseases.
KEGG ID
KEGG path
FDR
Status
hsa05169
Epstein-Barr virus infection
198
NA
Inhibited
hsa04612
Antigen processing and presentation
75
107
Activated
hsa05203
Viral carcinogenesis
205
NA
Activated
hsa04510
Focal adhesion
201
329
Activated
hsa04810
Regulation of actin cytoskeleton
212
322
Activated
hsa03013
RNA transport
151
202
Inhibited
hsa05168
Herpes simplex infection
184
NA
Activated
hsa05164
Influenza A
173
NA
0.00019
Activated
hsa05323
Rheumatoid arthritis
91
119
0.000218
Inhibited
hsa05140
Leishmaniasis
72
99
0.000218
Activated
hsa05012
Parkinson's disease
111
138
0.000367
Inhibited
hsa05166
HTLV-I infection
260
NA
0.000542
Activated
hsa05110
Vibrio cholerae infection
54
90
Activated
hsa05322
Systemic lupus erythematosus
131
137
0.00269
Activated
hsa04062
Chemokine signaling pathway
188
268
0.00287
Activated
hsa05130
Pathogenic Escherichia coli infection
54
88
0.00334
Activated
hsa04914
Progesterone-mediated oocyte maturation
86
152
0.00334
Inhibited
hsa05016
Huntington's disease
168
218
0.00381
Inhibited
hsa05134
Legionellosis
55
NA
0.00389
Inhibited
hsa04670
Leukocyte transendothelial migration
115
175
0.00484
Inhibited
hsa05416
Viral myocarditis
70
107
0.0118
Activated
hsa05131
Shigellosis
61
112
0.0133
Activated
hsa05152
Tuberculosis
179
NA
0.0133
Activated
hsa04141
Protein processing in endoplasmic reticulum
163
236
0.0172
Activated
hsa05100
Bacterial invasion of epithelial cells
70
123
0.0236
Activated
hsa04660
T cell receptor signaling pathway
108
169
0.0266
Activated
hsa05145
Toxoplasmosis
133
193
0.027
Inhibited
hsa05150
Staphylococcus aureus infection
55
62
0.027
Activated
hsa04540
Gap junction
89
130
0.027
Activated
hsa05032
Morphine addiction
92
NA
0.027
Activated
hsa04940
Type I diabetes mellitus
43
54
0.0303
Inhibited
hsa04380
Osteoclast differentiation
132
193
0.0346
Activated
hsa04650
Natural-killer-cell-mediated cytotoxicity
134
189
0.0346
Inhibited
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
68
100
0.0361
Activated
hsa03018
RNA degradation
69
97
0.0475
Inhibited
: number of significantly changed genes in the pathway; : number of genes in the pathway; FDR: false discovery rate.
