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BioMed Research International
Volume 2014, Article ID 409837, 7 pages
http://dx.doi.org/10.1155/2014/409837
Research Article

Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice

1Department of Physiology, Medical College of Nanchang University, Nanchang 330006, China
2Department of Pathophysiology, Medical College of Nanchang University, Nanchang 330006, China
3Library of Nanchang University, Nanchang 330006, China
4Nanchang Medical School, Nanchang 330006, China

Received 25 October 2013; Accepted 19 January 2014; Published 2 March 2014

Academic Editor: Erhan Unlu

Copyright © 2014 Bei Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice.