BioMed Research International / 2014 / Article / Tab 5

Research Article

Antioxidants, Phytochemicals, and Cytotoxicity Studies on Phaleria macrocarpa (Scheff.) Boerl Seeds

Table 5

In vitro, cytotoxic effects of methanol extract and its fractions of P. macrocarpa cancer cells lines and normal human fibroblast breast cells line.

Cell lineIncubation periods (hours)MEHFCFEAFDoxorubicin

248.2 ± 4.66≥10010.0 ± 1.315.6 ± 1.170.92 ± 0.64
Ca Ski4819.7 ± 0.92≥1008.2 ± 1.047.7 ± 1.850.69 ± 1.05
7240.7 ± 2.26≥10022.0 ± 1.866.0 ± 3.220.45 ± 0.99

2412.0 ± 2.245.2 ± 1.4957.5 ± 2.6422.3 ± 1.581.05 ± 1.08
MCF7488.5 ± 1.6855.5 ± 1.9740.0 ± 1.4816.8 ± 1.700.12 ± 0.69
726.3 ± 2.5072.5 ± 1.5246.5 ± 3.458.4 ± 1.710.92 ± 1.70

2429.3 ± 2.2640.0 ± 3.159.5 ± 2.951.1 ± 1.200.92 ± 0.72
HT294825.0 ± 1.3564.0 ± 2.038.7 ± 1.593.5 ± 2.000.32 ± 2.16
7221.5 ± 3.3075.0 ± 3.1421.0 ± 1.9812 ± 2.280.88 ± 0.94

2416.5 ± 2.5240.5 ± 3.5224.8 ± 2.066.8 ± 1.81.02 ± 1.79
SKOV-34822.1 ± 2.4750.0 ± 3.0216.5 ± 3.216.5 ± 2.30.32 ± 0.97
7236.0 ± 3.5570.3 ± 3.539.0 ± 2.63.2 ± 2.810.62 ± 0.98

24≥100≥100≥1006.5 ± 2.30.43 ± 0.50
MDA-MB23148≥100≥100≥10015 ± 3.430.59 ± 1.01
72≥100≥100≥10018.6 ± 1.260.95 ± 1.32

ME: methanol extract; HF: hexane fraction; EAF: ethyl acetate fraction; CF: chloroform fraction; WF: water fraction. Doxorubicin was used as positive control.
Each value is expressed as mean ± standard deviation of three measurements.