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BioMed Research International
Volume 2014, Article ID 410341, 6 pages
Review Article

Treatment of Acute Pulmonary Embolism: Update on Newer Pharmacologic and Interventional Strategies

1Department of Heart and Great Vessels “Attilio Reale”, Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy
2Respiratory Diseases Unit, “Sapienza” University, Rome, Italy
3Department of Internal Medicine, Division of Cardiology, University of North Texas Health Science Center, Fort Worth, TX, USA
4Anthea Hospital, GVM Care & Research, ES Health Science Foundation, Italy

Received 10 April 2014; Accepted 13 April 2014; Published 15 June 2014

Academic Editor: Salvatore Rosanio

Copyright © 2014 Francesco Pelliccia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acute pulmonary embolism (PE) is a common complication in hospitalized patients, spanning multiple patient populations and crossing various therapeutic disciplines. Current treatment paradigm in patients with massive PE mandates prompt risk stratification with aggressive therapeutic strategies. With the advent of endovascular technologies, various catheter-based thrombectomy and thrombolytic devices are available to treat patients with massive or submassive PE. In this paper, a variety of newer treatment strategies for PE are analyzed, with special emphasis on various interventional treatment strategies. Clinical evidence for utilizing endovascular treatment modalities, based on our institutional experience as well as a literature review, is provided.