On the Coupling of Two Models of the Human Immune Response to an Antigen

Algorithm 1

Main program for the coupled models.

(1) begin

(2) Initialize();

(3) createFiles();

(4) while ((𝑡<𝑖𝑡𝑒𝑟𝑃𝑒𝑟𝐷𝑎𝑦∗𝑛𝑢𝑚𝐷𝑎𝑦𝑠) && (𝐴>𝑡𝑜𝑙)) do

(5)  calcIntegrals();

(6)  solveODEs(); // systemic response model

(7)  solvePDEs(); // local response model

(8)  recordResults();

(9) end

(10) end