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BioMed Research International
Volume 2014 (2014), Article ID 410480, 9 pages
http://dx.doi.org/10.1155/2014/410480
Research Article

Primary Genetic Investigation of a Hyperlipidemia Model: Molecular Characteristics and Variants of the Apolipoprotein E Gene in Mongolian Gerbil

Yuehuan Liu,1,2 Jiusheng Wu,1 Qiaojuan Shi,2 Honggang Guo,2 Huazhong Ying,2 and Ningying Xu1

1College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
2Zhejiang Academy of Medical Sciences, Hangzhou 310013, China

Received 22 January 2014; Revised 6 May 2014; Accepted 8 May 2014; Published 1 June 2014

Academic Editor: Qinghua Nie

Copyright © 2014 Yuehuan Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. M. Kris-Etherton and J. Dietschy, “Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: human and animal studies,” The American Journal of Clinical Nutrition, vol. 65, no. 5, supplement 1, pp. 1590S–1596S, 1997. View at Google Scholar
  2. H. D. Ramachandran, K. Narasimhamurthy, and P. L. Raina, “Modulation of cholesterol induced hypercholesterolemia through dietary factors in indian desert gerbils (Meriones hurrianae),” Nutrition Research, vol. 23, no. 2, pp. 245–256, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. P. J. Babin and G. F. Gibbons, “The evolution of plasma cholesterol: direct utility or a “spandrel” of hepatic lipid metabolism?” Progress in Lipid Research, vol. 48, no. 2, pp. 73–91, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. D. M. Hegsted and A. Gallagher, “Dietary fat and cholesterol and serum cholesterol in the gerbil,” Journal of Lipid Research, vol. 8, no. 3, pp. 210–214, 1967. View at Google Scholar · View at Scopus
  5. M. P. Sullivan, J. J. Cerda, F. L. Robbins, C. W. Burgin, and R. J. Beatty, “The gerbil, hamster, and guinea pig as rodent models for hyperlipidemia,” Laboratory Animal Science, vol. 43, no. 6, pp. 575–578, 1993. View at Google Scholar · View at Scopus
  6. M. T. Zhong, M. Huang, and J. Lu, “Establishment of a rapid hyperlipidemic gerbil model,” Acta Laboratorium Animalis Scientia Sinica, vol. 14, no. 3, pp. 217–221, 2006. View at Google Scholar
  7. H. Z. Ying, C. H. Yu, Z. Y. Wang, B. Yu, J.-M. Zang, and Y.-H. Liu, “Characterization and mechanisms of lipid metabolism in high-fat diet induced hyperlipidemia gerbil model,” African Journal of Biotechnology, vol. 11, no. 97, pp. 16347–16352, 2012. View at Google Scholar
  8. H. K. Das, J. McPherson, G. A. Bruns, S. K. Karathanasis, and J. L. Breslow, “Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene,” The Journal of Biological Chemistry, vol. 260, no. 10, pp. 6240–6247, 1985. View at Google Scholar
  9. K. S. Meir and E. Leitersdorf, “Atherosclerosis in the apolipoprotein E-deficient mouse: a decade of progress,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 6, pp. 1006–1014, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Knoblauch, A. Bauerfeind, C. Krähenbühl et al., “Common haplotypes in five genes influence genetic variance of LDL and HDL cholesterol in the general population,” Human Molecular Genetics, vol. 11, no. 12, pp. 1477–1485, 2002. View at Google Scholar · View at Scopus
  11. S. H. Zhang, R. L. Reddick, J. A. Piedrahita, and N. Maeda, “Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E,” Science, vol. 258, no. 5081, pp. 468–471, 1992. View at Google Scholar · View at Scopus
  12. G. Utermann, U. Langenbeck, U. Beisiegel, and W. Weber, “Genetics of the apolipoprotein E system in man,” The American Journal of Human Genetics, vol. 32, no. 3, pp. 339–347, 1980. View at Google Scholar · View at Scopus
  13. J. D. Smith, A. Melian, T. Leff, and J. L. Breslow, “Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements,” The Journal of Biological Chemistry, vol. 263, no. 17, pp. 8300–8308, 1988. View at Google Scholar · View at Scopus
  14. A. S. Plump, J. D. Smith, T. Hayek et al., “Severe hypercholesterolemia and atherosclerosis in apolipoprotein E- deficient mice created by homologous recombination in ES cells,” Cell, vol. 71, no. 2, pp. 343–353, 1992. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Gao, K. Li, S. Y. Tang, and Y. Xiao, “Study on animal models for hyperlipidemia,” Journal of Hygiene Research, vol. 31, no. 2, pp. 97–99, 2002. View at Google Scholar · View at Scopus
  16. H. Z. Ying, Y. H. Liu, B. Yu, Z.-Y. Wang, J.-N. Zang, and C.-H. Yu, “Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils,” Food and Chemical Toxicology, vol. 52, pp. 53–60, 2013. View at Publisher · View at Google Scholar
  17. N. Gaudreault, N. Kumar, V. R. Olivas et al., “Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic apoe mice,” PLoS ONE, vol. 7, no. 5, article e35816, 2012. View at Google Scholar
  18. W. Li, Q. J. Shi, H. G. Guo et al., “Study on the formation and mechanism of NAFLD in three different rodents,” Chinese Comparative Medical, vol. 20, no. 1, pp. 76–80, 2012. View at Google Scholar
  19. D. K. Spady and J. M. Dietschy, “Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster,” The Journal of Clinical Investigation, vol. 81, no. 2, pp. 300–309, 1988. View at Google Scholar · View at Scopus
  20. L. Chan, “Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins,” The Journal of Biological Chemistry, vol. 267, no. 36, pp. 25621–25624, 1992. View at Google Scholar · View at Scopus
  21. A. Pronczuk, P. Khosla, and K. C. Hayes, “Dietary myristic, palmitic, and linoleic acids modulate cholesterolemia in gerbils,” The FASEB Journal, vol. 8, no. 14, pp. 1191–1200, 1994. View at Google Scholar · View at Scopus
  22. L. Difrancesco, N. H. Mercer, and D. H. Percy, “The Mongolian gerbil as an animal model for the study of atherosclerosis,” The FASEB Jounal, vol. 3, article 618, 1989. View at Google Scholar
  23. L. S. Dieter and S. Estus, “Isoform of APOE with retained intron 3; quantitation and identification of an associated single nucleotide polymorphism,” Molecular Neurodegeneration, vol. 5, no. 1, article 34, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. J. J. Ramsoondar, E. B. Rucker, J. C. Vasquez et al., “Isolation and genetic characterization of the porcine apolipoprotein E gene,” Animal Genetics, vol. 29, no. 1, pp. 43–47, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. D. M. Church, V. A. Schneider, T. Graves et al., “Modernizing reference genome assemblies,” PLoS Biology, vol. 9, no. 7, article e1001091, 2011. View at Publisher · View at Google Scholar
  26. R. A. Gibbs, G. M. Weinstock, M. L. Metzker et al., “Genome sequence of the Brown Norway rat yields insights into mammalian evolution,” Nature, vol. 428, no. 6982, pp. 493–521, 2004. View at Publisher · View at Google Scholar
  27. K. Lindblad-Toh, C. M. Wade, T. S. Mikkelsen et al., “Genome sequence, comparative analysis and haplotype structure of the domestic dog,” Nature, vol. 438, no. 7069, pp. 803–819, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Scally, J. Y. Dutheil, L. W. Hillier et al., “Insights into hominid evolution from the gorilla genome sequence,” Nature, vol. 483, no. 7388, pp. 169–175, 2012. View at Publisher · View at Google Scholar
  29. M. S. Boguski, N. Elshourbagy, J. M. Taylor, and J. I. Gordon, “Comparative analysis of repeated sequences in rat apolipoproteins A-I, A-IV, and E,” Proceedings of the National Academy of Sciences of the United States of America, vol. 82, no. 4, pp. 992–996, 1985. View at Google Scholar · View at Scopus
  30. S. C. Williams, S. M. Bruckheimer, A. J. Lusis, R. C. LeBoeuf, and A. J. Kinniburgh, “Mouse apolipoprotein A-IV gene: nucleotide sequence and induction by a high-lipid diet,” Molecular and Cellular Biology, vol. 6, no. 11, pp. 3807–3814, 1986. View at Google Scholar · View at Scopus
  31. S. M. Fullerton, A. V. Buchanan, V. A. Sonpar et al., “The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster,” Human Genetics, vol. 115, no. 1, pp. 36–56, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. S. C. Rall Jr., K. H. Weisgraber, and R. W. Mahley, “Human apolipoprotein E the complete amino acid sequence,” The Journal of Biological Chemistry, vol. 257, no. 8, pp. 4171–4178, 1982. View at Google Scholar
  33. J. Zhang, W. W. Zeng, B. S. Chen et al., “Analysis of apolipoprotein E cDNA and protein structure of tree shrew,” Chinese Jounal of Biochemistry and Molecular Biology, vol. 18, no. 1, pp. 9–13, 2002. View at Google Scholar
  34. J. W. Mclean, C. Fukazawa, and J. M. Taylor, “Rat apolipoprotein E mRNA (cloning and sequencing of double-stranded cDNA),” The Journal of Biological Chemistry, vol. 258, no. 14, pp. 8993–9000, 1983. View at Google Scholar
  35. M. Murakami, Y. Ushio, Y. Morino, T. Ohta, and Y. Matsukado, “Immunohistochemical localization of apolipoprotein E in human glial neoplasms,” The Journal of Clinical Investigation, vol. 82, no. 1, pp. 177–188, 1988. View at Google Scholar · View at Scopus
  36. C.-T. Lin, Y. F. Xu, J.-Y. Wu, and L. Chan, “Immunoreactive apolipoprotein E is a widely distributed cellular protein,” The Journal of Clinical Investigation, vol. 78, no. 4, pp. 947–958, 1986. View at Google Scholar
  37. D. A. Nickerson, S. L. Taylor, S. M. Fullerton et al., “Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene,” Genome Research, vol. 10, no. 10, pp. 1532–1545, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. Q. Y. Guo, S. F. Long, P. Fan et al., “Study on the apolipoprotein E polymorphism in Chinese maonan ethnic minority,” Modern Preventive Medicine, vol. 38, no. 2, pp. 324–326, 2011. View at Google Scholar
  39. X. H. Zhou, X. M. Luo, Y. Hong et al., “Association study of apolipoprotein E gene polymorphism and Alzheimer disease in Xinjiang Uygur population and Han population,” Chinese Journal of Psychiatry, vol. 41, no. 4, pp. 220–224, 2008. View at Google Scholar
  40. S. Li, H. Zhang, P. Gao, Z. Chen, C. Wang, and J. Li, “A functional mutation at position -155 in porcine APOE promoter affects gene expression,” BMC Genetics, vol. 12, article 40, 2011. View at Publisher · View at Google Scholar · View at Scopus