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BioMed Research International
Volume 2014 (2014), Article ID 413249, 8 pages
http://dx.doi.org/10.1155/2014/413249
Research Article

Increased Serum Levels of Inflammatory Mediators and Low Frequency of Regulatory T Cells in the Peripheral Blood of Preeclamptic Mexican Women

1Immunobiology Laboratory, Hospital Juárez de México, Ministry of Health, 07760 Mexico City, Mexico
2Research Directorate, Hospital Juárez de México, Ministry of Health, 07760 Mexico City, Mexico
3Molecular Genetics Laboratory, Hospital Juárez de México, Ministry of Health, 07760 Mexico City, Mexico

Received 2 July 2014; Accepted 15 September 2014; Published 7 December 2014

Academic Editor: Gail B. Mahady

Copyright © 2014 Mario Adan Moreno-Eutimio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Regulatory T cells (; CD4+CD2Foxp3+) are critical in maintaining immune tolerance during pregnancy and uterine vascularization. In this study, we show that, in Mexican women with different preeclamptic severity levels, the number of and the subset of CD4+CD2Foxp3+ are decreased compared with those of normotensive pregnant women (NP). Moreover, a systemic inflammatory state is a pivotal feature in the pathogenesis of this disorder and could be related to hypertension and endothelial dysfunction. Likewise, we observed elevated levels of IL-6, TNF-α, and IL-8 in the serum of severe preeclamptic patients (SPE); no differences were found in the IL-1β and IL-10 levels compared with those of NP patients. An analysis of chemokines in the preeclamptic serum samples showed high levels of CXCL10, CCL2, and CXCL9. Our findings suggest that the preeclamptic state is linked with systemic inflammation and reduced numbers of .