Research Article
CCR7 Regulates Cell Migration and Invasion through JAK2/STAT3 in Metastatic Squamous Cell Carcinoma of the Head and Neck
Table 1
Correlations between CCR7, STAT3 phosphorylation expression and clinicopathological factors of SCCHN.
| Clinicopathological characteristics | Number of cases | CCR7 | Statistical analysis |
STAT3 phosphorylation | Statistical analysis | +~+++ | − | +~+++ | − |
| Age | | | | | | | | ≥60 | 40 | 25 | 15 | = 0.032 | 25 | 15 | = 0.422 | <60 | 38 | 23 | 15 | 21 | 17 | Gender | | | | | | | | Male | 50 | 32 | 18 | = 0.357 | 30 | 20 | = 0.061 | Female | 28 | 16 | 12 | 16 | 12 | Tumor size | | | | | | | | T1, T2 | 65 | 37 | 28 | = 3.510 | 36 | 29 | = 2.077 | T3, T4 | 13 | 11 | 2 | 10 | 3 | Clinical stage | | | | | | | | I, II | 37 | 15 | 22 | = 13.113* | 14 | 23 | = 12.998* | III, IV | 41 | 33 | 8 | 32 | 9 | Nodal metastasis | | | | | | | | Yes | 37 | 29 | 8 | = 8.434* | 29 | 8 | = 10.954* | No | 41 | 19 | 22 | 17 | 24 |
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< 0.05 (the internal difference of CCR7 or STAT3 phosphorylation expression within clinicopathological characteristics).
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