Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats
Gross examination of the gastric mucosa in rats. (a) Untreated rats (normal control). Intact gastric mucosa tissues are seen; (b) rats pretreated with 0.5% CMC (5 mL/kg, ulcer control). Severe lesions are seen with extensive visible haemorrhagic necrosis of gastric mucosa; (c) rats pretreated with omeprazole (20 mg/kg, positive control). Mild lesions of gastric mucosa are observed compared to the lesions in ulcer control group; (d) rats pretreated with low dose of C. xanthorrhiza leaf extract (250 mg/kg); (e) rats pretreated with high dose of C. xanthorrhiza leaf extract (500 mg/kg). No lesions are formed which indicates full protection of plant extract against gastric ulcers. The black arrow indicates the presence of gastric lesions.