BioMed Research International / 2014 / Article / Fig 9

Research Article

Caspase-14 Expression Impairs Retinal Pigment Epithelium Barrier Function: Potential Role in Diabetic Macular Edema

Figure 9

Schematic diagram demonstrates the proposed role of caspase-14 in the hyperglycemia-induced RPE barrier dysfunction and its potential role in DME. Hyperglycemia upregulates caspase-14 level/activity in the RPE cells modulating the activity of both caspase-1 and caspase-9 and promoting the proinflammatory and proapoptotic responses to hyperglycemia, respectively.