Application of Ultrasound on Monitoring the Evolution of the Collagen Fiber Reinforced nHAC/CS Composites In Vivo

Table 2

Calcification and degradation characteristics of scaffolds at each time point.

Time (w)	Calcification rate (%) (mean ± SD)			Degradation rate (%) ( mean ± SD )			Calcification rate/degradation rate
	Scaffold	Scaffold/BMSCs	P value	Scaffold	Scaffold/BMSCs	P value	Scaffold	Scaffold/BMSCs	P value
1	4.07 ± 0.4	4.43 ± 0.9	0.389	8.41 ± 1.1	8.84 ± 0.7	0.445	0.49 ± 0.02	0.5 ± 0.08	0.688
2	6.36 ± 1.4	7.97 ± 2.2	0.157	14.94 ± 2.4	13.21 ± 2.6	0.258	0.42 ± 0.04	0.62 ± 0.18	0.042*
4	13.76 ± 3.6	15.96 ± 0.8	0.201	25.1 ± 4.3	20.91 ± 3.3	0.09	0.55 ± 0.1	0.78 ± 0.12	0.004**
6	18.55 ± 4.5	27.27 ± 2	0.001**	35.21 ± 2.6	35.68 ± 7.5	0.888	0.52 ± 0.11	0.78 ± 0.12	0.003**
8	31.16 ± 8.5	42.83 ± 7.3	0.023*	54.44 ± 6.8	56.49 ± 1.7	0.504	0.57 ± 0.11	0.76 ± 0.13	0.021*
10	40.69 ± 7.2	55.25 ± 8.3	0.009**	67.32 ± 2.7	64.3 ± 4.4	0.636	0.61 ± 0.11	0.83 ± 0.12	0.007**
12	55.65 ± 6	66.23 ± 7.2	0.02*	75.59 ± 5.3	76.89 ± 4.3	0.649	0.74 ± 0.05	0.86 ± 0.1	0.02*

∗P < 0.05, **P < 0.01.