Diagnostic and Prognostic Value of Soluble Syndecan-1 in Pleural Malignancies

Table 2

Cut-offs were derived from the maximum sensitivity × specificity in respective receiver operator characteristic curve.

Biomarker	Fluid	Cut-off (ng/mL)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Syndecan-1	Pl. effs	65.7	74.9	61.3	0.77	0.57
Syndecan-1	Sera	151.6	46.1	59.1	0.70	0.27
Osteopontin	Pl. effs	2034.0	65.5	61.1	0.60	0.65
Osteopontin	Sera	217.3	52.7	60.6	0.77	0.34

Pl. effs: pleural effusions; PPV: positive predictive value; NPV: negative predictive value.