|
Reference, year | Study population | Sample size | Study type | Brief description | Key findings and comments |
|
Dangas et al., 2005 [7] | CKD and non-CKD | 7,230 |
P.O | 1,980 pts with CKD and 5,250 without CKD used to determine predictors of CIN in PCI | Taking an ACE-I was associated with a lower risk of CIN in CKD pts |
|
Toprak, 2006 [23] | Near normal renal function | 80 | RCT | 42 pts received captopril while 32 controls received no captopril | CIN occurred 2.5x more in the captopril group |
|
Dadpey et al., 2007 [29] | Normal renal function undergoing PCI | 240 | RCT | 60 pts in each of four gps of ACI-I, diuretics, with a 36 hours discontinuation of these drugs as controls | Neither diuretic nor ACE-I discontinuation or continuation increased the risk of CIN |
|
Spatz et al., 2012 [11] | Stage III-IV CKD | 178 | R | Pts were either on ACE-I, ARB, or both | RAAS blockade before PCI did not increase CIN risk |
|
Bariş et al., 2013 [37] | Near normal renal function | 295 | P.O | Pts in 3gps of ACE-I () ARB (), and control group on no RAAS () | Chronic usage of ACE-I and ARB increases the risk of CIN |
|
Cirit et al., 2006 [25] | >65 yrs with mild-moderate CKD | 230 | P.O | One gp on ACE-I for 2 months versus gp without ACE-I before PCI | ACE-I increased risk of CIN |
|
Rosenstock et al., 2008 [28] | Stage III-IV CKD | 281 | RCT | Pts on ACE-I/ARBs with therapy stopped 24 hrs before or continued compared to control before PCI | No difference in postprocedure creatinine, eGFR, and incident CIN in the 3 groups |
|
Hölscher et al., 2008 [24] | Adults with creatinine of 1.5 to 3.5 mg/dL | 412 | Post hoc RCT | ACE-I administered to pts for elective PCI in the Dialysis-versus-Diuresis (DVD) trial | ACE-I therapy increased risk of CIN 6-fold |
|
Umruddin et al., 2012 [26] | Pts with multiple risk factors | 201 | R, case control | Exposure to ACE-I/ARB was determined in the two gps | Exposure to ACE-I or ARB doubled the risk of CIN |
|
Rim et al., 2012 [27] | Adults undergoing elective PCI. | 5,300 | R | Study compared 1322 users of ACE-I or ARBs and 1322 nonusers matched by propensity scoring | CIN was higher in ACE-I/ARB than in nonusers (11.4% versus 6.3%; ) |
|
Gupta et al., 1999 [30] | Adults with diabetes mellitus | 71 | RCT | Captopril administered 1 hr before angiography versus none for the control gp | Exposure to captopril reduced risk of CIN by 79% |
|
Li et al., 2012 [31] | Pts in RCTs involving ACE-Is | 792 | Meta-analysis of RCTS | Searches in PubMed, MEDLINE, the Cochrane Central Register of Controlled Trials, and ISI Web of Science for impact of the ACE-Is on frequency of CIN | [ACE-Is use protective] in pts with diabetes mellitus but showed no protection or harm in other pts |
|