Novel Resveratrol and 5-Fluorouracil Coencapsulated in PEGylated Nanoliposomes Improve Chemotherapeutic Efficacy of Combination against Head and Neck Squamous Cell Carcinoma

Table 4

Regression coefficients obtained using different kinetic models for the release of resveratrol and 5-FU from different liposomes.

Drug	Release condition	Zero order; (𝑅^2)	First order; (𝑅^2)	Higuchi model; (𝑅^2)	Peppas model
					(𝑅^2)	𝑛
Res	PBS, pH 7.4	0.654	0.358	0.880	0.937	0.462
	Simulated saliva, pH 6.8	0.778	0.447	0.932	0.950	0.412
	Dual loaded liposomes in; PBS (pH 7.4)	0.782	0.430	0.957	0.962	0.436
	Dual loaded liposome in simulated saliva (pH 6.8)	0.768	0.413	0.939	0.952	0.443
	Dual loaded PEGylated liposomes in PBS (pH; 7.4)	0.790	0.427	0.946	0.955	0.458
	Dual loaded PEGylated liposomes in simulated saliva (pH 6.8)	0.870	0.466	0.979	0.957	0.529
5-FU	PBS (pH 7.4)	0.976	0.711	0.956	0.974	0.772
	Simulated saliva (pH 6.8)	0.971	0.735	0.95	0.972	0.758
	Dual loaded liposomes in; PBS (pH 7.4)	0.987	0.708	0.958	0.967	0.846
	Dual loaded liposomes in simulated saliva (pH 6.8)	0.985	0.692	0.965	0.971	0.811
	Dual loaded PEGylated liposomes in PBS (pH; 7.4)	0.992	0.751	0.900	0.958	1.014
	Dual loaded PEGylated liposomes in simulated saliva (pH 6.8)	0.954	0.614	0.968	0.974	0.753