Novel Resveratrol and 5-Fluorouracil Coencapsulated in PEGylated Nanoliposomes Improve Chemotherapeutic Efficacy of Combination against Head and Neck Squamous Cell Carcinoma

Table 6

Combination index (CI) of individually loaded resveratrol liposomes and 5-FU liposomes.

Res; (μm)	5-FU (μm)	CI grade
5	0.25	− − − − − (very strong antagonism)
	0.5	− − − − − (very strong antagonism)
	1	− − − − − (very strong antagonism)
	2	− − (moderate antagonism)
	5	− − (moderate antagonism)
10	0.25	− − − − − (very strong antagonism)
	0.5	+ + (moderate synergism)
	1	+ + + (synergism)
	2	− (slight antagonism)
	5	− (slight antagonism)
20	0.25	− − − − − (very strong antagonism)
	0.5	+ + + + (strong synergism)
	1	+ + + (synergism)
	2	+ + (moderate synergism)
	5	± (nearly additive)
30	0.25	+ + + + (strong synergism)
	0.5	+ + + + (strong synergism)
	1	+ + + (synergism)
	2	+ + + (synergism)
	5	+ + (moderate synergism)