The Longitudinal Assessment of Osteomyelitis Development by Molecular Imaging in a Rabbit Model
Figure 2
Imaging data. (a) Sequential X-ray radiographs during follow-up. The surgical procedure can result in radiologic symptoms for osteolysis (small arrow head). Two weeks after surgery, periosteal elevation can be detected (solid arrow head). After four weeks, cortical thickening (double headed arrow) and osteolysis can be detected (asterisk). At six weeks, the osteolysis is affecting the entire proximal part of the tibia (hash sign). Graph depicts the increase in radiological score during the developmental stage of an osteomyelitis. Radiological scores during follow-up were compared to the preoperative radiological score, asterisk indicates , and error bars indicate standard error of mean. (b) Representative postmortem micro-CT images taken after the six-week follow-up. (c) Reconstructed 18F-FDG micro-PET data shows an increased tracer uptake in the operated area during the experimental follow-up (arrow). Asterisk indicates and error bars indicate standard error of mean.
