Circadian Modulation of the Cl⁻ Equilibrium Potential in the Rat Suprachiasmatic Nuclei

Figure 1

Spontaneous GABAergic postsynaptic currents in the suprachiasmatic nucleus. GABA sPSCs were pharmacologically isolated by administration of the ionotropic glutamate receptor antagonists, DNQX (10 μM) and APV (50 μM). Recordings at 0 mV and −70 mV are shown. Subsequent bicuculline administration (10 μM) completely abolished the sPSCs at all membrane holding potentials. Example recordings obtained in a dorsal SCN neuron during the day period in perforated patch configuration.