Table 1: Acute toxic effects in rodent i.p. exposed to dichloromethane (DCM), chloroform (CLF) or toluene (TOL).

VOCDose (mmol/kg)P-450CYP2E1Lipid peroxidationGSHMNPCECAReference

DCM2.50000Pilot study
CLF2.60+0.4800Pilot study
TOL8−0.48+0.5000Pilot study

DCM1.2–2.400[23]
4.8–9.5+0.4–0.50+0.35[23]
60[24]
5–200[25]
1.2–23.50[26]

CLF0.10[27]
1.3000[28]
1.7−0.07[27]
2.0–8.00[25]
0.01+3.75[21]
0.1–1.0+7.75[21]

TOL50+1.16[29]
5.40[9]
10.8+0.30[9]
16.2+0.17[9]
200[30]
1.200[31]
2.4+0.320[31]
4.70+2.71[31]

Data represent significant fold increases (+) or decreases (−) with respect to control animals; zero means no change.
Cytochrome P450 (P-450), cytochrome 2E1 (CYP2E1), lipid peroxidation and glutathione (GSH) were determined in liver, micronuclei (MNPCE) and chromosomal aberrations (CA) were determined in bone marrow.