Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy

Table 1

Distribution of 3′-UTR gene polymorphism (SNP4065) of urokinase gene among idiopathic membranous nephropathy and healthy control subjects.

Genotype	MN; (N = 91)	Control; (N = 105)	P value
Male gender	50 (54)	61 (58)	0.325^a
Age (yrs)	57.8 ± 16.4	49.8 ± 14.4	0.000^b
Genotype of urokinase gene
C/C	82 (90%)	90 (86%)	0.237^c
C/T	9 (10%)	15 (14%)
T/T	0 (0%)	0 (0%)
Allelic frequency
C	173 (95)	195 (93)	0.238^a
T	9 (5)	15 (7)
Allelic carriage
C	91 (100)	105 (100)	0.318^a
T	9 (10)	15 (14)

Number in the parenthesis is percentage.
^aYates’ correction of contingency.
^bMann–Whitney U test.
^cChi-square test.
Patient age, which was used as a covariate to adjust the genotype in the study population by multinomial logistic regression, as not significantly different between control and MN groups.