Urokinase Gene 3′-UTR T/C Polymorphism Is Associated with Malignancy and ESRD in Idiopathic Membranous Nephropathy

Table 4

The malignant neoplasm in C/C genotype of 3′-UTR of urokinase gene polymorphism in MN patients and their presentation.

Malignancy	Malignancy duration (yrs)			Management
	Diagnosis	Renal failure	Mortality
Lymphoma (3)
Diffuse large B cell lymphoma, brain	25.0	Before	2.6/death	Chemotherapy
Malignant lymphoma, mixed large and small cleaved cell,; B phenotype, with bone marrow involvement, stage IV	5.5	1.7/function	1.7/death	Chemotherapy
Angioimmunoblastic T-cell lymphoma	5.5	0.1/function	0.1/death	No
Skin cancer (2)
Basal cell carcinoma, left nasal base and medial canthus	15.5	1.7/function	1.7/death	Incision
Squamous cell carcinoma, skull	2.9	2.2/failure	3/death	Incision
GI tract malignancy (3)
Adenocarcinoma, stomach	15.0	0.1/function	0.1/death	No
Adenocarcinoma, stomach	7.6	2.5/function	2.5/survival	Subtotal gastrectomy
Adenocarcinoma, rectum	6.2	7.3/function	7.3/survival	polypectomy
GU tract malignancy (2)
Prostate adenocarcinoma	9.5	Before	5.9/death	Radical prostatectomy
Renal cell carcinoma, left kidney	3.2	4.3/failure	5.2/death	Left nephrectomy
Gynecology malignancy (2)
Squamous cell carcinoma, cervix	10.9	1.2/function	1.2/survival	Vaginal hysterectomy
Squamous cell carcinoma, cervix	10.6	Before	2.3/survival	Vaginal hysterectomy
Respiratory tract (1)
Adenocarcinoma, LLL, lung	11.9	0.6/function	0.6/death	Chemotherapy

Before: renal failure before diagnosis of malignancy.