Early Intra-Articular Complement Activation in Ankle Fractures
Table 1
Correlation of intra-articular protein levels with age, serum CRP at second day after surgery, BMI, ASA classification, and period between fracture and punction [h]. Statistical tests refer to correlations to the absolute protein concentrations and the protein concentrations in relation to TPC. Data indicate degradation of extracellular matrix of cartilage and activation of complement over time following fracture. Spearman’s and values are only provided in case of statistical significance; in these cases, all values ranged within the 95% CI.
Age
Postoperative CRP
BMI
ASA
Period fracture/punction [h]
TPC
Corr. coefficient
—
−0.64
—
—
—
Valid cases
8
8
8
8
8
Signif. ()
N.s.
0.0428
n.s.
N.s.
N.s.
Aggrecan/ Aggrecan/TPC
Corr. coefficient
—/—
—/—
—/—
—/—
0.74/0.81
Valid cases
8
8
8
8
8
Signif. ()
N.s./n.s.
N.s./n.s.
N.s./n.s.
N.s./n.s.
0.001/0.005
bFGF/bFGF/TPC
Corr. coefficient
—/—
—/—
—/—
—/—
—/—
Valid cases
8
8
8
8
8
Signif. ()
N.s./n.s.
N.s./n.s.
N.s./n.s.
N.s./n.s.
N.s./n.s.
IL-1/IL-1/TPC
Corr. coefficient
—/—
—/0.64
—/—
—/—
—/—
Valid cases
8
8
8
8
8
Signif. (P)
N.s./n.s.
n.s./0.0428
N.s./n.s.
N.s./n.s.
N.s./n.s.
IGF-1/IGF-1/TPC
Corr. coefficient
—/—
—/—
—/—
—/—
—/—
Valid cases
8
8
8
8
8
Signif. ()
N.s./n.s.
N.s./n.s.
N.s./n.s.
N.s./n.s.
N.s./n.s.
C3a/C3a/TPC
Corr. coefficient
—/—
—/—
—/—
0.65/—
—/—
Valid cases
8
8
8
8
8
Signif. ()
N.s./n.s.
N.s./n.s.
N.s./n.s.
0.0391/n.s.
N.s./n.s.
C5a/C5a/TPC
Corr. coefficient
—/—
—/—
—/—
—/—
—/—
Valid cases
8
8
8
8
8
Signif. ()
N.s./n.s.
N.s./n.s.
N.s./n.s.
N.s./n.s.
N.s./n.s.
C5b-9/C5b-9/TPC
Corr. coefficient
—/—
—/—
—/—
—/—
—/0.81
Valid cases
8
8
8
8
8
Signif. ()
N.s./n.s.
N.s./n.s.
N.s./n.s.
N.s./n.s.
N.s./0.007
BMI: body mass index; ASA: Physical Status Classification System of the American Society of Anesthesiologists; TPC: total protein content; CI: confidence interval; signif. (): value for statistical significance; Corr. coefficient: correlation coefficient (Spearman’s ); N.s.: not significant.
