Role of MicroRNA-1 in Human Cancer and Its Therapeutic Potentials

Table 1

Altered expression of miR-1 in different cancers.

Cancer type	miR-1 downregulation	miR-1 target genes	Reference number
Lung cancer	Primary lung cancer tissue and serum	MET; FoxP1; HDAC4; Slug; PIK3CA	[33, 36–38]
Colon cancer	Different colon cancer tissues	MET	[43]
Genitourinary cancer	Cancer cell lines and tissues	LASP1; TAGLN2; SRSF9; PTMA; PNP1	[50, 56, 57]
Head and neck cancer	Laryngeal carcinoma and MSSCC	TAGLN2; PTMA; FN1; PNP	[61, 62]
Thyroid cancer	Thyroid adenomas and carcinomas	CCND2; CXCR4; CXCL12	[66]
Hepatocellular cancer	HCC cell lines and tumor tissues	MET; FoxP1; HDAC4; ET-1	[39–41]
Sarcoma	Sarcoma cell lines and sarcoma tissues	MET; CCND2; HDAC4	[68, 69, 73]