Role of MicroRNA-1 in Human Cancer and Its Therapeutic Potentials

Table 2

Oncogenes and oncogenic pathway targets of miR-1 in cancers.

Gene name	Genbank accession number	Chromosome location	Functions	Reference number
Met	NM_000245.2	7q31	Proto-oncogenic receptor tyrosine kinase	[42, 44, 68]
HDAC4	NM_006037.3	2q37.3	Histone deacetylase activity; represses transcription	[14, 31, 39]
Pim-1	NM_002648.3	6p21.2	Proto-oncogene	[33]
FOXP1	NM_001244810.1	3p14.1	Regulate gene transcription; tumor suppressor	[33, 39]
TAGLN2	NM_003564.1	1q21-q25	Earliest marker of differentiated smooth muscle	[50, 56, 64]
PNP	NM_000270.3	14q13.1	Purine metabolism	[50, 58]
PTMA	NM_002823.4	2q37.1	Enhance cell-mediated immunity	[58]
CXCR4	NM_001008540.1	2q21	Chemokine receptor	[65]
CCND2	NM_001759.3	12p13	Regulator of cyclin-dependent kinase	[65, 71]
SRSF9	NM_003769.2	12q24.31		[57]
FN1	NM_212482.1	2q34	Involved in cell adhesion, growth, and migration	[61]
ETS1	NM_001143820.1	11q23.3	Proto-oncogene	[40]
Endothelin 1	NM_001955.4	6p24.1	Involved in vascular disorders	[41]
Slug	NM_003068.4	8q11	Transcriptional repressor and has antiapoptotic activity	[38]
CXCL12	NM_199168.3	10q11.1	Chemotactic for lymphocytes	[65]