New Researches and Application Progress of Commonly Used Optical Molecular Imaging Technology

Figure 10

High-resolution NIRF molecular imaging of cysteine proteinase activity in atherosclerosis. (a) Aorta from atherosclerotic (athero) rabbits injected with Prosense VM110 1 day earlier and imaged with the intravascular NIRF catheter; (b) ex vivo fluorescence reflectance imaging (FRI) at 800 nm; (c) ex vivo NIRF-white light fusion image; (d) aortas from atherosclerotic rabbits injected with saline and imaged in vivo with the NIRF catheter; (e) ex vivo FRI at 800 nm; (f) ex vivo NIRF-white light fusion image; (g) normal rabbit injected with VM110 and imaged with the intravascular NIRF catheter; (h) ex vivo FRI at 800 nm (1 s) and (i) ex vivo NIRF-white light fusion image. Adapetd from Jaffer et al. [89].