New Researches and Application Progress of Commonly Used Optical Molecular Imaging Technology
Figure 12
Reverse complementary multimodal imaging of miR9-involved neurogenesis of P19 cells. P19 cells cotransfected with the CMV/TfR/3XPT_miR9 and the CMV/Fluc were incorporated into a prewetted matrigel. The P19 cell-incorporated matrigels treated either without (−) or with (+) RA for neuronal induction were implanted into the right thigh (white arrow) and left thigh (white arrow) of a nude mouse, respectively (). MR images ((a), 1.5T), bioluminescence images, (b) and fluorescence images (c) were acquired for 2 days. MR images of the mouse bearing P19 cells without treatment of RA in the left thigh and with treatment of RA in the right thigh were acquired before and after IV injection of the MF targeting TfR nanoparticles. Adapted from Jo et al. [91].
