New Researches and Application Progress of Commonly Used Optical Molecular Imaging Technology
Figure 2
Bioluminescence imaging of disease progression in Tg(CRND8:Gfap-luc) mice. (a) Bioluminescence signals comparison results of Tg CRND8:Gfap-luc mice (red; ) and Tg Gfap-luc mice (blue; ). Tg(CRND8:Gfap-luc) mice showed a statistically prominent increase in BLI beginning at 7 months of age. (b) BLI signals from the brains of 12-months-old Tg(CRND8:Gfap-luc) mice (upper) are significant compared with age-matched Tg(Gfap-luc) controls (lower). (c) Immunohistochemistry on the brain of a 12-months-old Tg(CRND8:Gfap-luc) mouse showed prominent luciferase (upper) and GFAP (lower) staining in astrocytes within the hippocampus. Adapted from Watts et al. [40].
