BioMed Research International / 2014 / Article / Tab 1

Research Article

Anticancer Drug 2-Methoxyestradiol Protects against Renal Ischemia/Reperfusion Injury by Reducing Inflammatory Cytokines Expression

Table 1

Kidney weight and serum BUN and creatinine levels in renal ischemia/reperfusion (I/R) mice combined with or without 2ME2 treatment.

Sham controlI/R-onlyI/R + 2ME2 (10 mg/kg, i.p.)I/R + 2ME2 (20 mg/kg, i.p.)

Kidney weight (%)1.04 ± 0.352.16 ± 1.65*1.38 ± 0.67#1.15 ± 0.43#
BUN (mg/dL)18.80 ± 1.9052.70 ± 12.50*28.70 ± 1.70#21.40 ± 3.50#
Creatinine (g/dL)0.14 ± 0.031.66 ± 0.14*0.28 ± 0.06#0.19 ± 0.04#

Sham control: mice undergoing the same procedure without occlusion of the renal pedicle; I/R-only: mice given renal I/R challenge combined with vehicle (normal saline) treatment; I/R + 2ME2: mice given I/R combined with 2ME2 (10 or 20 mg/kg, i.p.) treatment; and i.p.: intraperitoneally. Kidney weight (%): percentage of body weight of each kidney. Values are mean ± SD. All groups: . * compared with sham control mice; # compared with I/R-only mice.