Anticancer Drug 2-Methoxyestradiol Protects against Renal Ischemia/Reperfusion Injury by Reducing Inflammatory Cytokines Expression

Table 1

Kidney weight and serum BUN and creatinine levels in renal ischemia/reperfusion (I/R) mice combined with or without 2ME2 treatment.

	Sham control	I/R-only	I/R + 2ME2 (10 mg/kg, i.p.)	I/R + 2ME2 (20 mg/kg, i.p.)
Kidney weight (%)	1.04 ± 0.35	2.16 ± 1.65*	1.38 ± 0.67^#	1.15 ± 0.43^#
BUN (mg/dL)	18.80 ± 1.90	52.70 ± 12.50*	28.70 ± 1.70^#	21.40 ± 3.50^#
Creatinine (g/dL)	0.14 ± 0.03	1.66 ± 0.14*	0.28 ± 0.06^#	0.19 ± 0.04^#

Sham control: mice undergoing the same procedure without occlusion of the renal pedicle; I/R-only: mice given renal I/R challenge combined with vehicle (normal saline) treatment; I/R + 2ME2: mice given I/R combined with 2ME2 (10 or 20 mg/kg, i.p.) treatment; and i.p.: intraperitoneally. Kidney weight (%): percentage of body weight of each kidney. Values are mean ± SD. All groups: . * compared with sham control mice; ^# compared with I/R-only mice.