Cell Death and Deubiquitinases: Perspectives in Cancer

Figure 2

DUBs regulating cell death pathways. The figure illustrates the deubiquitinases regulating different pathways involved in cell death and cell growth in the perspective of cancer cells. The DUBs remove K48 (green), K63 (pink), and K11 (blue) linked Ub chains from their substrates. In some cases, the specific linkage remains unknown (?). The role of some of the DUBs is unclear in terms of deubiquitination of the substrate, but there is interaction (indicated by ⇔). Activation is represented by (→) and inhibition by (⊤).