|
| Deubiquitinase | Substrate | Hydrolyzes Ub-linkage | Relevance in cell death |
|
| Ubiquitin specific proteases |
| USP1 | FANCD2 | — | Activates Chk1 |
| PCNA | — | |
| PHLPP | K48 | Inhibits Akt to induce apoptosis |
| USP2 | Cyclin D1 | K48 | Cell cycle progression |
| Mdm2 | K48 | Inhibition of p53 |
| MdmX | K48 | Inhibition of p53 |
| Fas | K63 | Inhibition of NFB signaling |
| USP2a | RIP1 | K63 | Inhibition of NFB signaling |
| TRAF2 | K63 | Inhibition of NFB signaling |
| USP3 + BRCC36 | Rap80 | K63 | Maintain G2/M checkpoints on DSBs |
| USP4 | Rb, p107, p130 | Associates | Cell cycle arrest |
| TCF4 | — | Suppresses -catenin transcription |
| p53 | K48 | p53 stabilization |
| USP7 (HAUSP) | PTEN | K63 | PCa progression |
| p53 | K48 | Apoptosis |
| Rb | K48 | Differential regulation |
| Mdm2/MdmX | K48 | Inhibits p53 |
| Daxx | — | Regulates Mdm2 activity under stress |
| p53/Mule | — | Indirect regulation of p53 |
| H2B, Mdm2 | — | Regulates chromatin remodelling |
| Tip60 | K48 | p53 dependent apoptosis |
| Chfr | — | Enhanced ubiquitination of HDAC1 and upregulation of p21 |
| ERCC6 | — | Stabilizes RNA Pol II-ERCC6 complex |
| Claspin | K48 | Chk1 regulation |
| FOXO 3a and 4 | K63 | Accumulation of p27 |
| RIP1 | K63 | Positive regulation of TNF- induced apoptosis |
| p65-NFB | — | Upregulates NFB target gene transcription |
| USP8 | ErbB3 via Nrdp1 | — | Activation of EGFR pathway |
| USP9X | Mcl-1 | K48 | Radioresistance |
| USP10 | p53 | K48 | Stabilizes p53 |
| USP11 | IB | — | Inhibition of NFB signaling by sequestering NFB in the cytoplasm |
| USP12 | PHLPP | K48 | Inhibition of Akt to induce apoptosis |
| USP15 | APC | K48 | Promotes -catenin |
| IKK- | K48 | Inhibition of NFB signaling and activation of p53 |
| USP19 | KPC1 | — | Accumulation of p27 |
| USP21 | RIP1 | K63 | Inhibition of NFB signaling |
| USP28 | cMyc | K48 | Reverses FBW7- mediated ubiquitination |
| Chk2 | K48 | Chk2-p53-PUMA apoptosis |
| USP29 | p53 | K48 | Stabilization of p53 |
| USP37 | Cyclin A | K48 | Induction of G1/S |
| USP39 | Aurora B | — | SAC integrity |
| USP42 | p53 | K48 | Enhances p53 stability |
| USP44 | Mad2/cdc20 | — | Inhibits APC/Ccdh1 complex |
| USP46 | PHLPP | K48 | Inhibition of Akt to induce apoptosis |
| USP47 | DNA Pol | — | BER response |
| USP50 | Wee1 | K48 | Prevents mitotic entry |
|
| Ubiquitin carboxy-terminal hydrolases |
| UCH-L1 | Jab1 | Colocalizes | Inbihits p27 |
| BAP1 | BRCA-1 | — | Induction of G1/S |
| YY-1 | — | Induction of G1/S |
| HCF-1 | — | Induction of G1/S |
| CYLD | Plk-1 | — | G2/M protection |
| NEMO | K63 | Inhibition of NFB signaling |
| TRAF 2, 6 and 7 | K63 | Inhibition of NFB signaling |
| RIP1 | K63 | Inhibition of NFB signaling |
| TAK1 | K63 | Inhibition of NFB signaling |
| BCL-3 | — | Induction of p50-BCL3 and p52-BCL3 complexes inhibiting cell proliferation |
|
| Ovarian tumor proteases |
| A20 | RIP1 | K63 | Inhibition of NFB signaling |
| TRAF6 | K63 | Inhibition of NFB signaling |
| Caspase 8 | K63 | Regulates caspase 8 activity |
| OTUB1 | Ubc13 | Associates | Inhibits RNF168 |
| OTUD5 | p53 | K48 | Induction of apoptosis |
| Cezanne (OTUD7B) | RIP1 | K11 | Inhibition of NFB signaling |
| EGFR | — | Enhances EGFR signaling |
| TRABID/ZRANB1 | APC | K63 | Induction of TCF4/-catenin transcription |
|
| JAMM/MPN domain-associated metallopeptidase |
| AMSH | EGFR | K63 | Regulates endocytic trafficking of EGFR |
| BRCC36 | H2A, H2AX | K63 | At sites of DSBs |
| POH1 | ErbB2 | — | Regulates EGFR signaling |
|
| Monocyte chemotactic protein-induced proteases |
| MCPIP1 | RIP1 | K63 | Inhibition of NFB signaling |
| TRAF2 and 6 | K63 | Inhibition of NFB signaling |
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