Heat Shock Protein 70 in Alzheimer’s Disease

Figure 2

HSP70 as a therapeutic strategy for AD. Endogenous stimulus and exogenous utilization elevate the level of HSP70, which inhibit the cytotoxicity of Aβ, tauopathy in brain, and apoptosis in AD. Efforts to promote HSP72 expression and inhibit HSC70 could accelerate tau clearance, which attenuate tauopathy. Inhibitors of the ATPase activity of HSP70 reduced pathogenic tau in brain.