Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats
Figure 1
Paraffin sections stained by haematoxylin and eosin (H&E, ×200) for histopathological examination of liver tissues of rats as follows: control group (a) showing normal hepatocytes architecture (H), central vein (C.V), and normal blood sinusoids (S); (b) liver tissue of group 2 (lead acetate + Omega-3, 125 mg/kg body weight); (c) liver tissue of group 3 (lead acetate + Omega-3, 260 mg/kg body weight) showing histological alterations induced by lead acetate that were markedly reduced in groups 2 and 3. Liver tissue of group 4 (lead acetate treated rats) (d1 and d2) showing distended and hemorrhage in the portal vein (), loss of the normal architecture, degenerated hepatocytes with pyknotic nuclei (□), and degenerated hepatocytes with vacuolated cytoplasm (). Condensed nuclei () and lymphocytes aggregation (L) inside the hepatic tissue.