Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 437852, 11 pages
http://dx.doi.org/10.1155/2014/437852
Research Article

Comparison of the Freiburg and Charlson Comorbidity Indices in Predicting Overall Survival in Elderly Patients with Newly Diagnosed Multiple Myeloma

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea

Received 25 March 2014; Revised 29 May 2014; Accepted 18 June 2014; Published 10 July 2014

Academic Editor: Dong Soon Lee

Copyright © 2014 Sung Min Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Y. Kristinsson, O. Landgren, P. W. Dickman, Å. R. Derolf, and M. Björkholm, “Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003,” Journal of Clinical Oncology, vol. 25, no. 15, pp. 1993–1999, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Kleber, G. Ihorst, B. Deschler et al., “Detection of renal impairment as one specific comorbidity factor in multiple myeloma: multicenter study in 198 consecutive patients,” European Journal of Haematology, vol. 83, no. 6, pp. 519–527, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Kleber, G. Ihorst, J. Udi, B. Koch, R. Wsch, and M. Engelhardt, “Prognostic risk factor evaluation in patients with relapsed or refractory multiple myeloma receiving lenalidomide treatment: analysis of renal function by eGFR and of additional comorbidities by comorbidity appraisal,” Clinical Lymphoma, Myeloma & Leukemia, vol. 12, no. 1, pp. 38–48, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. E. Eleftherakis-Papapiakovou, E. Kastritis, M. Roussou et al., “Renal impairment is not an independent adverse prognostic factor in patients with multiple myeloma treated upfront with novel agent-based regimens,” Leukemia & lymphoma, vol. 52, no. 12, pp. 2299–2303, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Palumbo, S. Bringhen, H. Ludwig et al., “Personalized therapy in multiple myeloma according to patient age and vulnerability: a report of the European Myeloma Network (EMN),” Blood, vol. 118, no. 17, pp. 4519–4529, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Nanda, M. Chen, M. H. Braccioforte, B. J. Moran, and A. V. D'Amico, “Hormonal therapy use for prostate cancer and mortality in men with coronary artery disease-induced congestive heart failure or myocardial infarction,” The Journal of the American Medical Association, vol. 302, no. 8, pp. 866–873, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. J. A. Meyerhardt, P. J. Catalano, D. G. Haller et al., “Impact of diabetes mellitus on outcomes in patients with colon cancer,” Journal of Clinical Oncology, vol. 21, no. 3, pp. 433–440, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. P. J. Goodwin, M. Ennis, K. I. Pritchard et al., “Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study,” Journal of Clinical Oncology, vol. 20, no. 1, pp. 42–51, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. G. R. Simon, M. Extermann, A. Chiappori et al., “Phase 2 trial of docetaxel and gefitinib in the first-line treatment of patients with advanced nonsmall-cell lung cancer (NSCLC) who are 70 years of age or older,” Cancer, vol. 112, no. 9, pp. 2021–2029, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Gay and A. Palumbo, “Management of older patients with multiple myeloma,” Blood Reviews, vol. 25, no. 2, pp. 65–73, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Kleber, G. Ihorst, M. Terhorst et al., “Comorbidity as a prognostic variable in multiple myeloma: comparative evaluation of common comorbidity scores and use of a novel MM-comorbidity score,” Blood Cancer Journal, vol. 1, no. 9, article e35, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. T. S. Field, J. L. F. Bosco, M. N. Prout et al., “Age, comorbidity, and breast cancer severity: impact on receipt of definitive local therapy and rate of recurrence among older women with early-stage breast cancer,” Journal of the American College of Surgeons, vol. 213, no. 6, pp. 757–765, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. M. L. Sorror, M. B. Maris, B. Storer et al., “Comparing morbidity and mortality of HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative and myeloablative conditioning: influence of pretransplantation comorbidities,” Blood, vol. 104, no. 4, pp. 961–968, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Labonté, T. Iqbal, M. A. Zaidi et al., “Utility of comorbidity assessment in predicting transplantation-related toxicity following autologous hematopoietic stem cell transplantation for multiple myeloma,” Biology of Blood and Marrow Transplantation, vol. 14, no. 9, pp. 1039–1044, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Offidani, L. Corvatta, C. Polloni et al., “Assessment of vulnerability measures and their effect on survival in a real-life population of multiple myeloma patients registered at marche region multiple myeloma registry,” Clinical Lymphoma, Myeloma and Leukemia, vol. 12, no. 6, pp. 423–432, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. W. R. Sperr, F. Wimazal, M. Kundi et al., “Comorbidity as prognostic variable in MDS: comparative evaluation of the HCT-CI and CCI in a core dataset of 419 patients of the Austrian MDS study group,” Annals of Oncology, vol. 21, no. 1, Article ID mdp258, pp. 114–119, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. E. Charlson, P. Pompei, K. A. Ales, and C. R. MacKenzie, “A new method of classifying prognostic comorbidity in longitudinal studies: development and validation,” Journal of Chronic Diseases, vol. 40, no. 5, pp. 373–383, 1987. View at Publisher · View at Google Scholar · View at Scopus
  18. A. S. Levey, L. A. Stevens, C. H. Schmid et al., “A new equation to estimate glomerular filtration rate,” Annals of Internal Medicine, vol. 150, no. 9, pp. 604–612, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. I. de Kock, M. Mirhosseini, F. Lau et al., “Conversion of Karnofsky Performance Status (KPS) and Eastern Cooperative Oncology Group Performance Status (ECOG) to Palliative Performance Scale (PPS), and the interchangeability of PPS and KPS in prognostic tools,” Journal of Palliative Care, vol. 29, no. 3, pp. 163–169, 2013. View at Google Scholar
  20. C. Ma, S. Bandukwala, D. Burman et al., “Interconversion of three measures of performance status: an empirical analysis,” European Journal of Cancer, vol. 46, no. 18, pp. 3175–3183, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. M. M. Oken, R. H. Creech, and D. C. Tormey, “Toxicology and response criteria of the Eastern Cooperative Oncology Group,” The American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 5, no. 6, pp. 649–655, 1982. View at Google Scholar · View at Scopus
  22. S. A. Ataergin, T. Kindwall-Keller, N. A. Berger, and H. M. Lazarus, “New generation pharmacotherapy in elderly multiple myeloma patients,” Expert Opinion on Pharmacotherapy, vol. 10, no. 1, pp. 81–98, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Palumbo, F. Davies, M. Kropff et al., “Consensus guidelines for the optimal management of adverse events in newly diagnosed, transplant-ineligible patients receiving melphalan and prednisone in combination with thalidomide (MPT) for the treatment of multiple myeloma,” Annals of Hematology, vol. 89, no. 8, pp. 803–811, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. A. A. Chanan-Khan, S. Lonial, D. Weber et al., “Lenalidomide in combination with dexamethasone improves survival and time-to-progression in patients ≥65 years old with relapsed or refractory multiple myeloma,” International Journal of Hematology, vol. 96, no. 2, pp. 254–262, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. J.-L. Harousseau and M. Dreyling, “Multiple myeloma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up,” Annals of Oncology, vol. 21, supplement 5, pp. v155–v157, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Palumbo, M. Attal, and M. Roussel, “Shifts in the therapeutic paradigm for patients newly diagnosed with multiple myeloma: Maintenance therapy and overall survival,” Clinical Cancer Research, vol. 17, no. 6, pp. 1253–1263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Barosi, G. Merlini, A. Billio et al., “SIE, SIES, GITMO evidence-based guidelines on novel agents (thalidomide, bortezomib, and lenalidomide) in the treatment of multiple myeloma,” Annals of Hematology, vol. 91, no. 6, pp. 875–888, 2012. View at Publisher · View at Google Scholar · View at Scopus