Comparison of the Freiburg and Charlson Comorbidity Indices in Predicting Overall Survival in Elderly Patients with Newly Diagnosed Multiple Myeloma

Table 4

Univariate and multivariate Cox’s regression analysis for overall survival.

	Univariate analysis			Multivariate analysis
	𝑃 value	HR	95% CI	𝑃 value	HR	95% CI
ECOG	0.002	1.951	1.287–2.958	0.009	1.890	1.176–3.038
0-1
≥2
Chronic lung disease	0.028	1.941	1.073–3.510	0.300	1.425	0.730–2.778
Yes
No
eGFR (mL/min/1.73 m^2)	0.012	2.139	1.183–3.869	0.228	1.515	0.771–2.976
>30
≤30
Any tumor	0.001	3.513	1.678–7.356	0.003	3.717	1.617–8.554
Yes
No
Metastatic solid tumor	<0.001	44.034	8.449–229.485	<0.001	85.847	14.628–503.822
Yes
No
Cerebrovascular disease	0.016	3.064	1.228–7.641	0.210	1.855	0.706–4.887
Yes
No
International staging system	0.024			0.250
1
2
3
Age, years	0.339	1.242	0.796–1.938
65–74
≥75
Sex	0.692	0.920	0.610–1.388
Male
Female
Durie-Salmon stage	0.242
1
2
3
Myocardial infarct	0.146	1.783	0.818–3.884
Yes
No
Congestive heart failure	0.581	1.329	0.484–3.644
Yes
No
Connective tissue disease	0.302	0.047	0.000–15.543
Yes
No
Ulcer disease	0.196	0.571	0.244–1.334
Yes
No
Mild liver disease	0.262	2.246	0.545–9.249
Yes
No
DM	0.256	0.718	0.405–1.272
Yes
No
Hemiplegia	0.081	0.353	0.110–1.135
Yes
No
Moderate to severe renal disease	1.000	1.000	0.000–4.271E9
Yes
No
Moderate-severe liver disease	0.302	2.100	0.514–8.583
Yes
No
Initial chemotherapy regimen	0.844	1.058	0.603–1.858
Conventional agents
Novel agent
CCI	0.061	0.677	0.450–1.018
2-3
≥4
FCI	<0.001
0
1
2-3

HR, hazard ratio; CI, confidence interval; ECOG, eastern cooperative oncology group; eGFR, estimated glomerular filtration rate; DM, diabetes mellitus; CCI, Charlson comorbidity index; FCI, Freiburg comorbidity index.