Posttransplant Allosensitization in Low Immunological Risk Kidney and Kidney-Pancreas Graft Recipients
Table 3
Predictors of censored kidney graft loss by Cox proportional hazard analysis.
Hazard ratio
95% IC
-value
Univariable analysis
Recipient age
1.05
1.01–1.08
0.01
Male (versus female) recipient
0.58
0.23–1.46
0.26
Living (versus deceased) donor
0.04
0.01–5.87
0.20
Donor age
1.03
0.99–1.07
0.07
Male (versus female) donor
0.48
0.19–1.25
0.13
Delayed graft function
5.85
2.30–14.85
<0.01
ATG use
0.30
0.07–1.29
0.10
ABDR HLA mismatches >3
9.39
1.25–70.60
0.03
Time on dialysis ≥48 (versus <48) mo
2.05
0.79–5.28
0.14
Acute rejection
No episode
Reference
Steroid-sensitive
1.17
0.15–8.83
0.88
Steroid-insensitive
2.02
0.46–8.86
0.35
Kidney-pancreas recipient
0.62
0.14–2.72
0.53
Anti-HLA antibodies at 6 mo after transplant
Negative
Reference
Class I
0.71
0.09–5.46
0.74
Class II
4.79
1.07–21.40
0.04
Class I + II
10.95
3.08–38.96
<0.01
Multivariable analysis*
Recipient age
1.02
0.98–1.07
0.29
Donor age
1.02
0.98–1.06
0.45
ATG use
0.44
0.09–2.06
0.30
Delayed graft function
6.11
2.21–16.92
<0.01
ABDR HLA mismatches >3
10.17
1.32–78.55
0.03
Anti-HLA antibodies at 6 mo after transplant
Negative
Reference
Class I
1.23
0.15–10.11
0.85
Class II
5.12
1.07–24.53
0.04
Class I + II
13.79
3.41–55.77
<0.01
Variables included in the model are ATG use, recipient age, donor age, delayed graft function, ABDR mismatches, and anti-HLA antibodies screen. IC: confidence interval; ATG: antithymocyte globulin; mo: months; HLA: human leukocyte antigen.
