Novel Approach for Coexpression Analysis of E2F1–3 and MYC Target Genes in Chronic Myelogenous Leukemia

Table 2

Mapping coexpressed gene pairs to annotated gene pairs from each process network.

Process networks	Fisher’s exact test					FDR
					value
Development_Neurogenesis in general	14	11	11	14	0.286	0.251
Development_Hedgehog signaling	22	15	15	22	0.081	0.118
Signal transduction_WNT signaling	10	7	7	10	0.247	0.270
Signal transduction_TGF-beta, GDF, and activin signaling	6	5	5	6	0.500	0.365
Cell adhesion_Attractive and repulsive receptors	6	0	0	6	0.001	0.004
Development_Regulation of angiogenesis	8	2	2	8	0.012	0.026
Cardiac development_BMP_TGF_beta_signaling	2	1	1	2	0.500	0.313
Neurophysiological process_Melatonin signaling	3	2	2	3	0.500	0.274

: mapped normal-specific strongly coexpressed gene pairs; : mapped normal-specific weakly coexpressed gene pairs; : mapped CML-specific strongly coexpressed gene pairs; : mapped CML-specific weakly coexpressed gene pairs.