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BioMed Research International
Volume 2014, Article ID 452175, 12 pages
http://dx.doi.org/10.1155/2014/452175
Research Article

Differential Expression of Osteo-Modulatory Molecules in Periodontal Ligament Stem Cells in Response to Modified Titanium Surfaces

1Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul 130-701, Republic of Korea
2Department of Oral & Maxillofacial Surgery, School of Dentistry, Kyung Hee University, 26 Kyunghee-daero, Dongdaemun-gu, Seoul 130-701, Republic of Korea

Received 5 March 2014; Accepted 11 April 2014; Published 25 June 2014

Academic Editor: Seong-Hun Kim (Sunny)

Copyright © 2014 So Yeon Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. L. Cochran, R. K. Schenk, A. Lussi, F. L. Higginbottom, and D. Buser, “Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible,” Journal of Biomedical Materials Research, vol. 40, no. 1, pp. 1–11, 1998. View at Google Scholar
  2. T. W. Oates, P. Valderrama, M. Bischof et al., “Enhanced implant stability with a chemically modified SLA surface: a randomized pilot study,” The International Journal of Oral & Maxillofacial Implants, vol. 22, no. 5, pp. 755–760, 2007. View at Google Scholar · View at Scopus
  3. M. Kononen, M. Hormia, J. Kivilahti, J. Hautaniemi, and I. Thesleff, “Effect of surface processing on the attachment, orientation, and proliferation of human gingival fibroblasts on titanium,” Journal of Biomedical Materials Research, vol. 26, no. 10, pp. 1325–1341, 1992. View at Google Scholar · View at Scopus
  4. C. Oakley and D. M. Brunette, “Response of single, pairs, and clusters of epithelial cells to substratum topography,” Biochemistry and Cell Biology, vol. 73, no. 7-8, pp. 473–489, 1995. View at Google Scholar · View at Scopus
  5. X. Rausch-fan, Z. Qu, M. Wieland, M. Matejka, and A. Schedle, “Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast-like cells (MG63) in response to titanium surfaces,” Dental Materials, vol. 24, no. 1, pp. 102–110, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Olivares-Navarrete, S. L. Hyzy, J. H. Park et al., “Mediation of osteogenic differentiation of human mesenchymal stem cells on titanium surfaces by a Wnt-integrin feedback loop,” Biomaterials, vol. 32, no. 27, pp. 6399–6411, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Ge, N. Zhao, L. Wang et al., “Bone repair by periodontal ligament stem cell seeded nanohydroxyapatite-chitosan scaffold,” International Journal of Nanomedicine, vol. 7, pp. 5405–5414, 2012. View at Google Scholar
  8. N. An, A. Schedle, M. Wieland, O. Andrukhov, M. Matejka, and X. Rausch-Fan, “Proliferation, behavior, and cytokine gene expression of human umbilical vascular endothelial cells in response to different titanium surfaces,” Journal of Biomedical Materials Research A, vol. 93, no. 1, pp. 364–372, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. Qu, X. Rausch-Fan, M. Wieland, M. Matejka, and A. Schedle, “The initial attachment and subsequent behavior regulation of osteoblasts by dental implant surface modification,” Journal of Biomedical Materials Research A, vol. 82, no. 3, pp. 658–668, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Docheva, D. Padula, C. Popov et al., “Establishment of immortalized periodontal ligament progenitor cell line and its behavioural analysis on smooth and rough titanium surface,” European Cells & Materials, vol. 19, pp. 228–241, 2010. View at Google Scholar · View at Scopus
  11. B.-M. Seo, M. Miura, S. Gronthos et al., “Investigation of multipotent postnatal stem cells from human periodontal ligament,” The Lancet, vol. 364, no. 9429, pp. 149–155, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Y. Kim, J.-Y. Lee, Y.-D. Park, K. L. Kang, J.-C. Lee, and J. S. Heo, “Hesperetin alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of periodontal ligament stem cells,” PLoS ONE, vol. 8, no. 6, Article ID e67504, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976. View at Google Scholar · View at Scopus
  14. G. Zhao, Z. Schwartz, M. Wieland et al., “High surface energy enhances cell response to titanium substrate microstructure,” Journal of Biomedical Materials Research A, vol. 74, no. 1, pp. 49–58, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. Z. Schwartz, R. Olivares-Navarrete, M. Wieland, D. L. Cochran, and B. D. Boyan, “Mechanisms regulating increased production of osteoprotegerin by osteoblasts cultured on microstructured titanium surfaces,” Biomaterials, vol. 30, no. 20, pp. 3390–3396, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Altankov, F. Grinnell, and T. Groth, “Studies on the biocompatibility of materials: fibroblast reorganization of substratum-bound fibronectin on surfaces varying in wettability,” Journal of Biomedical Materials Research, vol. 30, no. 3, pp. 385–391, 1996. View at Google Scholar
  17. S. A. Hacking, E. Harvey, P. Roughley, M. Tanzer, and J. Bobyn, “The response of mineralizing culture systems to microtextured and polished titanium surfaces,” Journal of Orthopaedic Research, vol. 26, no. 10, pp. 1347–1354, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. J. H. Park, C. E. Wasilewski, N. Almodovar et al., “The responses to surface wettability gradients induced by chitosan nanofilms on microtextured titanium mediated by specific integrin receptors,” Biomaterials, vol. 33, no. 30, pp. 7386–7393, 2012. View at Publisher · View at Google Scholar
  19. B. O. Williams and K. L. Insogna, “Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone,” Journal of Bone and Mineral Research, vol. 24, no. 2, pp. 171–178, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. A. J. Mikels and R. Nusse, “Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context,” PLoS Biology, vol. 4, no. 4, article e115, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Kühl, L. C. Sheldahl, C. C. Malbon, and R. T. Moon, “Ca2+/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus,” The Journal of Biological Chemistry, vol. 275, no. 17, pp. 12701–12711, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Galli, G. Passeri, F. Ravanetti, E. Elezi, M. Pedrazzoni, and G. M. MacAluso, “Rough surface topography enhances the activation of Wnt/β-catenin signaling in mesenchymal cells,” Journal of Biomedical Materials Research A, vol. 95, no. 3, pp. 682–690, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. I. Wall, N. Donos, K. Carlqvist, F. Jones, and P. Brett, “Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro,” Bone, vol. 45, no. 1, pp. 17–26, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. E. J. Arnsdorf, P. Tummala, and C. R. Jacobs, “Non-canonical Wnt signalling and N-cadherin related β-catenin signalling play a role in mechanically induced osteogenic cell fate,” PLoS ONE, vol. 4, no. 4, Article ID e5388, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. F. Schwarz, M. Wieland, Z. Schwartz et al., “Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants,” Journal of Biomedical Materials Research B: Applied Biomaterials, vol. 88, no. 2, pp. 544–557, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. B. G. Keselowsky, L. Wang, Z. Schwartz, A. J. Garcia, and B. D. Boyan, “Integrin α5 controls osteoblastic proliferation and differentiation responses to titanium substrates presenting different roughness characteristics in a roughness independent manner,” Journal of Biomedical Materials Research A, vol. 80, no. 3, pp. 700–710, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. P. N. de Aza, Z. B. Luklinska, A. Martinez et al., “Morphological and structural study of pseudowollastonite implants in bone,” Journal of Microscopy, vol. 197, no. 1, pp. 60–67, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. M. I. Dishowitz, S. P. Terkhorn, S. A. Bostic, and K. D. Hankenson, “Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration,” Journal of Orthopaedic Research, vol. 30, no. 2, pp. 296–303, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. T. A. Mitsiadis, A. Feki, G. Papaccio, and J. Catón, “Dental pulp stem cells, niches, and notch signaling in tooth injury,” Advances in Dental Research, vol. 23, no. 3, pp. 275–279, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. W.-K. Kim, V. Meliton, N. Bourquard, T. J. Hahn, and F. Parhami, “Hedgehog signaling and osteogenic differentiation in multipotent bone marrow stromal cells are inhibited by oxidative stress,” Journal of Cellular Biochemistry, vol. 111, no. 5, pp. 1199–1209, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. G. L. Lin and K. D. Hankenson, “Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation,” Journal of Cellular Biochemistry, vol. 112, no. 12, pp. 3491–3501, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Han, C. Wu, J. Chang, and Y. Xiao, “The cementogenic differentiation of periodontal ligament cells via the activation of Wnt/β-catenin signalling pathway by Li+ ions released from bioactive scaffolds,” Biomaterials, vol. 33, no. 27, pp. 6370–6379, 2012. View at Publisher · View at Google Scholar