Review Article

Breast Cancer Risk in Rheumatoid Arthritis: An Update Meta-Analysis

Table 1

Summary of studies of RA and breast cancer incidence.

StudyCalendar period totalSources of RA patientsStyleMean/median follow-up (year)Breast cancer
(observed/expected)
Adjusted factors for SIRSIR (95% CI)

Mercer et al., (2013) [5]2002–20093,771The BSRBR (British Society for Rheumatology Biologics Register) Control Centre Consortium Population-based3.730/28.16Age, sex, and calendar year1.07 (0.72–1.52)
Infante-Rivard et al., (2012) [12]1976–20011,437Quebec Tumuor Registry, Quebec Institute of Statistics and Health, CanadaPopulation-based522/25.01Age, sex, and calendar year0.88 (0.58–1.34)
Yamada et al., (2011) [6]2001–20057,566IORRA (Institute of Rheumatology, Rheumatoid Arthritis formally known as J-ARAMIS)Population-basedNA20Age and sex 1.05 (0.64–1.62)
Chen et al., (2011) [7]1996–200723,644The National Health Research Institute of TaiwanPopulation-based5.90 ± 2.87123/101.44Age, sex, and calendar year1.21 (1.19–1.23)
Parikh-Patel et al., (2009) [13]1991–200284,475California’s Office of Statewide Planning and Health DevelopmentHospital-based4.8842/1343.5Age, sex, and race/ethnicity0.63 (0.59–0.67)
Abásolo et al., (2008) [14]1999–2005789The EMECAR cohort (Estudio de la Morbilidad y Expresion Clinica de la Artritis Reumatoide)Population-based3.952Age and sex0.90 (0.10–3.20)
Hemminki et al., (2008) [15]1980–200442,262The Swedish Hospital Discharge RegisterHospital-basedNA642Age, sex, period, region, and socioeconomic status0.97 (0.90–1.05)
Buchbinder et al., (2008) [16]1986–1998458Victorian State Cancer RegistryPopulation-based9.34/6.1Age, sex, and calendar year0.70 (0.20–1.70)
Wolfe and Michaud (2007) [17]1998–200513,869The US National Data Bank for Rheumatic DiseasesPopulation-based4.1102Age and sex0.80 (0.60–0.90)
Setoguchi et al., (2006) [18]NA29,422Health care utilization databases from US and CanadaPopulation-basedNA112/126.6Age and sex0.90 (0.73–1.06)
Askling et al., (2005) [19]1990–200353,067The Swedish Inpatient Register Hospital-based5.6471Age, sex, and calendar year0.83 (0.76–0.91)
Askling et al., (2005) [19] (Early RA)1995–20033,703The Early Arthritis Register Population-based3.613Age, sex, and calendar year0.60 (0.30–1.00)
Askling et al., (2005) [19] (TNF antagonist RA)1999–20034,160Swedish structured postmarketing surveillance programPopulation-based2.38Age, sex, and calendar year0.40 (0.20–0.90)
Thomas et al., (2000) [20]1981–199626,623Scottish Cancer RegistryHospital-based5.3249Age, sex, site, and calendar year0.95 (0.83–1.07)
Cibere et al., (1997) [21]1966–1974862Rheumatic Disease UnitPopulation-based17.418/22.8Age, sex, and calendar year0.90 (0.46–1.24)
Mellemkjær et al., (1996) [22]1977–1987 20,699Danish Hospital Discharge Register Hospital-based7186/229.8Age, sex, and calendar year0.80 (0.70–0.90)
Moritomo et al., (1995) [23]1980–1989655Center for Adult Diseases, Osaka, JapanPopulation-based103/1.79Age, sex, site, and calendar year1.68 (0.34–4.91)
Gridley et al., (1993) [24]1965–198311,683Swedish Hospital Inpatient RegisterHospital-based8.6106Age, sex, site, and calendar year0.79 (0.60–1.00)

N: the number of RA patients.
NA: not available.