¹⁸F-Labeled Silicon-Based Fluoride Acceptors: Potential Opportunities for Novel Positron Emitting Radiopharmaceuticals

Figure 1

(a) Approaches towards [¹⁸F]SiFA compounds for PET; [¹⁸F]SiFA can be obtained by either isotopic exchange or leaving group substitution from the suitable organosilane precursors. (b) Comparison of simplified reaction coordinates for IE and leaving group radiofluorination (from hydroxysilane in the absence of acid catalyst). Simple hypothetical siliconates intermediates are depicted. (Gas phase = dash blue lines, MeCN = dash black lines.)

(a)

(b)