Salvage Therapy of Multiple Myeloma: The New Generation Drugs

Table 1

Regimens containing bendamustine and novel agents.

Combination with novel agents: bortezomib					ORR	PFS	Reference
phase I-II	Bendamustine	90 mg	i.v.	Day 1 and day 4 every 28 days for up 8 cycles	52%	not reached	Berenson et al., 2013 [7]
	Bortezomib	1.0 mg/m^2		days 1, 4, 8, and 11 every 28 days for up 8 cycles
BVD phase II	Bendamustine	70 mg	i.v.	Day 1 and day 4 every 28 days for up 8 cycles	76%	9.7 months	Ludwig et al., 2014 [8]
	Bortezomib	1.3 mg/m^2	i.v.	Days 1, 4, 8, and 11 every 28 days for up 8 cycles
	Dexamethasone	20 mg	i.v.	Days 1, 4, 8, and 11 every 28 days for up 8 cycles
BVD phase II	Bendamustine	70 mg	i.v.	Day 1 and day 8 every 28 days for up 6 cycles	71.5%	16.5 months	Offidani et al., 2013 [9]
	Bortezomib	1.3 mg/m^2	i.v.	Days 1, 4, 8, and11 every 28 days for 2 cycles and then days 1, 8, 15, and 22 for 4 cycles
	Dexamethasone	20 mg	i.v./OS	Days 1-2, 4-5, 8-9, and 11-12 every 28 days for 2 cycles and then on days 1, 8, 15, and 22 for 4 cycles
BPV phase II	Bendamustine	60 mg	i.v.	Day 1 and day 2 every 28 days for up 7 cycles	69%	11 months	Ponish, 2012
	Bortezomib	1.3 mg/m^2	i.v.	Days 1, 4, 8, and 11 every 28 days for up 7 cycles
	Prednisone	100 mg	i.v.	Days 1, 2, 4, 8, and 11 every 28 days for up 7 cycles
Combination with novel agents: IMiDs
BTP phase I	Bendamustine	60 mg	i.v.	Day 1 and day 2 every 28 days up to maximum response or MTD	80%	11 months	Pönisch et al., 2008 [10]
	Thalidomide	50 or 100 or 200 mg	per OS	Days 1–21 every 28 days up to maximum response or MTD
	Prednisone	100 mg	i.v./per OS	Days 1, 2, 4, 8, and 11 every 28 days up to maximum response or MTD
BTD phase I-II	Bendamustine	60 mg	i.v.	Day 1 and day 8 every 28 days up to progression	46%	19 months	Yong et al., 2013 [11]
	Thalidomide	100 mg	per OS	Days 1–21 every 28 days up to progression
	Dexamethasone	20 mg	i.v./per OS	days 1, 8, 15, and 22 every 28 days up to progression
BLD	Bendamustine	75 mg	i.v.	Day 1 and day 2 every 28 days up to progression	76%	6.1 months	Lentzsch et al., 2012 [12]
	Lenalidomide	10 mg	per OS	Days 1–21 every 28 days up to progression
	Dexamethasone	40 mg	i.v./per OS	Days 1, 8, 15, and 22 every 28 days up to progression
BLP	Bendamustine	75 mg	i.v.	Day 1 and day 2 every 28 days up to progression	76%	48% at 18 months	Ponish, 2013
	Lenalidomide	25 mg	per OS	Days 1–21 every 28 days up to progression
	Prednisone	100 mg	per OS	Days 1–4 every 28 days up to progression