Table 2: Putative and validated interactions between the differentially expressed microRNAs and gene candidates specific to each dose of 60Co radiation.

Dose (Gy)miRNAFold changeTarget geneFold change

0.5hsa-miR-185-5p1.18TNFSF10 a−1.21
GLUL c−1.49

1hsa-miR-1071.0914 genescDecreased
hsa-miR-1441.60SELL −1.04
COTL −1.06
CEP63 −1.14
hsa-miR-17-5p1.09MCL1 a−1.26
FGL2 b−1.33
30 other genescDecreased
hsa-miR-185-5p1.0132 genescDecreased
hsa-miR-20b-5p1.0127 genescDecreased

5hsa-miR-142-3p−1.02MAP4K3 b1.32
DIRC2 b1.01
TIPARP b1.05
PDE4B c1.54
hsa-miR-142-5p−1.09AHR a1.31
SLC36A4 b1.11
hsa-miR-223-3p−1.27DUSP10 b,c1.07
EFNA1 b1.01
hsa-miR-451a−1.28SLC7A11 c1.14

Experimentally validated miRNA-gene interaction as identified by miRWalk.
bmiRNA-gene interaction predicted by at least four out of the five selected miRNA target prediction databases.
cmiRNA-gene interaction predicted by miRTar; the complete gene list is provided in Supplementary Material 1 (see Supplementary Material available online at