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BioMed Research International
Volume 2014, Article ID 456569, 7 pages
http://dx.doi.org/10.1155/2014/456569
Review Article

Platelet Function Tests: A Review of Progresses in Clinical Application

Department of Laboratory Medicine, Dong-A University College of Medicine, 1,3-Ga, Dongdaesin-dong, Seo-gu, Busan 602-715, Republic of Korea

Received 2 March 2014; Accepted 25 April 2014; Published 8 May 2014

Academic Editor: Mina Hur

Copyright © 2014 Jae-Lim Choi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. S. Smyth, S. Whiteheart, J. E. Italiano Jr., and B. S. Coller, “Platelet morphology, biochemistry, and function,” in Williams Hematology, chapter 114, pp. 1735–1814, 2010. View at Google Scholar
  2. P. Harrison and D. Keeling, “Platelet assays and platelet dysfunction,” in Laboratory Hematology Practice, chapter 37, pp. 480–491, 2012. View at Google Scholar
  3. C. N. Jenne, R. Urrutia, and P. Kubes, “Platelets: bridging hemostasis, inflammation, and immunity,” International Journal of Laboratory Hematology, vol. 35, no. 3, pp. 254–261, 2013. View at Google Scholar
  4. L. K. Jennings, “Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis,” Thrombosis and Haemostasis, vol. 102, no. 2, pp. 248–257, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. K. J. Clemetson, “Platelets and primary haemostasis,” Thrombosis Research, vol. 129, no. 3, pp. 220–224, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Abbate, G. Cioni, I. Ricci, M. Miranda, and A. M. Gori, “Thrombosis and Acute coronary syndrome,” Thrombosis Research, vol. 129, no. 3, pp. 235–240, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Harrison, “Testing platelet function,” Hematology/Oncology Clinics of North America, vol. 27, no. 3, pp. 411–441, 2013. View at Google Scholar
  8. R. Pakala and R. Waksman, “Currently available methods for platelet function analysis: advantages and disadvantages,” Cardiovascular Revascularization Medicine, vol. 16, no. 36, pp. 4041–4051, 2010. View at Google Scholar
  9. C. K. Hofer, A. Zollinger, and M. T. Ganter, “Perioperative assessment of platelet function in patients under antiplatelet therapy,” Expert Review of Medical Devices, vol. 7, no. 5, pp. 625–637, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. S. M. Picker, “In-vitro assessment of platelet function,” Transfusion and Apheresis Science, vol. 44, no. 3, pp. 305–319, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. E. J. Favaloro, G. Lippi, and M. Franchini, “Contemporary platelet function testing,” Clinical Chemistry and Laboratory Medicine, vol. 48, no. 5, pp. 579–598, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. B. E. Kehrel and M. F. Brodde, “State of the art in platelet function testing,” Transfusion Medicine and Hemotherapy, vol. 40, no. 2, pp. 73–86, 2013. View at Google Scholar
  13. M. Cattaneo, C. P. Hayward, K. A. Moffat, M. T. Pugliano, Y. Liu, and A. D. Michelson, “Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH,” Journal of Thrombosis and Haemostasis, vol. 7, no. 6, p. 1029, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. B. B. Dawood, G. C. Lowe, M. Lordkipanidze et al., “Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel,” Blood, vol. 120, no. 25, pp. 5041–5049, 2012. View at Google Scholar
  15. M. Cattaneo, C. Cerletti, P. Harrison et al., “Recommendations for the standardization of light transmission aggregometry: a consensus of the working party form the platelet physiology subcommittee of SSC/ISTH,” Journal of Thrombosis and Haemostasis, vol. 11, pp. 1183–1189, 2013. View at Google Scholar
  16. C. P. M. Hayward, P. Harrison, M. Cattaneo, T. L. Ortel, and A. K. Rao, “Platelet function analyzer (PFA)-100® closure time in the evaluation of platelet disorders and platelet function,” Journal of Thrombosis and Haemostasis, vol. 4, no. 2, pp. 312–319, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. E. J. Favaloro, “Clinical utility of the PFA-100,” Seminars in Thrombosis and Hemostasis, vol. 34, no. 8, pp. 709–733, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. C. D. Williams, G. Cherala, and V. Serebruany, “Application of platelet function testing to the bedside,” Thrombosis and Haemostasis, vol. 103, no. 1, pp. 29–33, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Hezard, A. Tessier-Marteau, and L. Macchi, “New insight in antiplatelet therapy monitoring in cardiovascular patients: from aspirin to thienopyridine,” Cardiovascular and Hematological Disorders-Drug Targets, vol. 10, no. 3, pp. 224–233, 2010. View at Google Scholar · View at Scopus
  20. J. R. Dahlen, M. J. Price, H. Parise, and P. A. Gurbel, “Evaluating the clinical usefulness of platelet function testing: considerations for the proper application and interpretation of performance measures,” Thrombosis and Haemostasis, vol. 109, no. 5, pp. 808–816, 2013. View at Google Scholar
  21. A. Afshari, A. Wikkelsø, A. M. Møller, J. Brok, and J. Wetterslev, “Thrombelastography (TEG) or thrombelastometry (ROTEM) to monitor haematotherapy versus usual care in patients with massive transfusion,” Cochrane Database of Systematic Reviews, vol. 3, pp. 1–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Kim, M. L. Quan, R. Y. Goh et al., “Comparison of prolonged prothrombin and activated partial thromboplastin time results with thrombeastograph parameters,” Laboratory Medicine, vol. 44, no. 4, pp. 319–323, 2013. View at Google Scholar
  23. S. L. Close, “Pharmacogenetics and pharmacogenomics of thienopyridines: clinically relevant?” Fundamental and Clinical Pharmacology, vol. 26, no. 1, pp. 19–26, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. W. O. Tobin, J. A. Kinsella, T. Coughlan et al., “High on-treatment platelet reactivity on commonly prescribed antiplatelet agents following transient ischaemic attack or ischaemic stroke: results from the Trinity Antiplatelet Responsiveness (TRAP) study,” European Journal of Neurology, vol. 20, no. 2, pp. 344–352, 2013. View at Google Scholar
  25. D. Capodanno, J. L. Ferreiro, and D. J. Angiolillo, “Antiplatelet therapy: new pharmacological agents and changing paradigms,” Journal of Thrombosis and Haemostasis, vol. 11, supplement 1, pp. 316–329, 2013. View at Google Scholar
  26. K. S. Woo, B. R. Kim, J. E. Kim et al., “Detemination of the prevalence of aspirin and clopidogrel resistances in patients with coronary artery disease by using various platelet-function tests,” Korean Journal of Laboratory Medicine, vol. 30, no. 5, pp. 460–468, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. K. E. Kim, K. S. Woo, R. Y. Goh et al., “Comparison of laboratory detection methods of aspirin resistance in coronary artery disease patients,” International Journal of Laboratory Hematology, vol. 32, no. 1, pp. 50–55, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. K. J. Smock, P. J. Saunders, G. M. Rodgers, and V. Johari, “Laboratory evaluation of clopidogrel responsiveness by platelet function and genetic methods,” American Journal of Hematology, vol. 86, no. 12, pp. 1032–1034, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Bonello, U. S. Tantry, R. Marcucci et al., “Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate,” Journal of the American College of Cardiology, vol. 56, no. 12, pp. 919–933, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Aradi, R. F. Storey, A. Komocsi et al., “Expert position paper on the role of platelet function testing in patients undergoing percutaneous coronary intervention,” European Heart Journal, vol. 35, no. 4, pp. 209–215, 2014. View at Google Scholar
  31. U. S. Tantry, L. Bonello, D. Aradi et al., “Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding,” Journal of the American College of Cardiology, vol. 62, no. 24, pp. 2261–2273, 2013. View at Google Scholar
  32. T. J. Kunicki and D. J. Nugent, “The genetics of normal platelet reactivity,” Blood, vol. 116, no. 15, pp. 2627–2634, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Z. Zhang, M. H. Kim, J. Y. Han, and Y. H. Jeong, “Defining predictive values using three different platelet function tests for CYP2C19 phenotype status on maintenance dual antiplatelet therapy after PCI,” Platelets, 2013. View at Google Scholar
  34. J. L. Choi, B. R. Kim, J. E. Kim et al., “Association between the microarray-based CYP2C19 genotyping assay and the platelet function test in cardiovascular patients receiving clopidogrel,” International Journal of Laboratory Hematology, 2014. View at Publisher · View at Google Scholar
  35. M. Prokopi, G. Pula, U. Mayr et al., “Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures,” Blood, vol. 114, no. 3, pp. 723–732, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. S. F. Mause and C. Weber, “Microparticles: protagonists of a novel communication network for intercellular information exchange,” Circulation Research, vol. 107, no. 9, pp. 1047–1057, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Aatonen, M. Grönholm, and P.-M. Siljander, “Platelet-derived microvesicles: multitalented participants in intercellular communication,” Seminars in Thrombosis and Hemostasis, vol. 38, no. 1, pp. 102–113, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. J. E. Italiano Jr., A. T. Mairuhu, and R. Flaumenhaft, “Clinical relevance of microparticles from platelets and megakaryocytes,” Current Opinion in Hematology, vol. 17, no. 6, pp. 578–584, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. E. Shantsila, P. W. Kamphuisen, and G. Y. H. Lip, “Circulating microparticles in cardiovascular disease: implications for atherogenesis and atherothrombosis,” Journal of Thrombosis and Haemostasis, vol. 8, no. 11, pp. 2358–2368, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. C. N. França, L. F. M. Pinheiro, M. C. O. Izar et al., “Endothelial progenitor cell mobilization and platelet microparticle release are influenced by clopidogrel plasma levels in stable coronary artery disease,” Circulation Journal, vol. 76, no. 3, pp. 729–736, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. L. M. Biasucci, I. Porto, L. D. Vito et al., “Differences in microparticle release in patients with acute coronary syndrome and stable angina,” Circulation Journal, vol. 76, no. 9, pp. 2174–2182, 2012. View at Google Scholar
  42. P. Lackner, A. Dietmann, R. Beer et al., “Cellular microparticles as a marker for cerebral vasospasm in spontaneous subarachnoid hemorrhage,” Stroke, vol. 41, no. 10, pp. 2353–2357, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. J. Thaler, C. Ay, H. Weinstabl et al., “Circulating procoagulant microparticles in cancer patients,” Annals of Hematology, vol. 90, no. 4, pp. 447–453, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Robert, P. Poncelet, R. Lacroix et al., “Standardization of platelet-derived microparticle counting using calibrated beads and a Cytomics FC500 routine flow cytometer: a first step towards multicenter studies?” Journal of Thrombosis and Haemostasis, vol. 7, no. 1, pp. 190–197, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. F. Mobarrez, J. Antovic, N. Egberg et al., “A multicolor flow cytometric assay for measurement of platelet-derived microparticles,” Thrombosis Research, vol. 125, no. 3, pp. e110–e116, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. R. Lacroix, S. Robert, P. Poncelet, R. S. Kasthuri, N. S. Key, and F. Dignat-George, “Standardization of platelet-derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop,” Journal of Thrombosis and Haemostasis, vol. 8, no. 11, pp. 2571–2574, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Dangwal and T. Thum, “MicroRNAs in platelet biogenesis and function,” Thrombosis and Haemostasis, vol. 108, no. 4, pp. 599–604, 2012. View at Google Scholar
  48. L. C. Edelstein, S. E. McKenzie, C. Shaw, M. A. Holinstat, S. P. Kunapuli, and P. F. Bray, “MicroRNAs in platelet production and activation,” Journal of Thrombosis and Haemostasis, vol. 11, supplement 1, pp. 340–350, 2013. View at Google Scholar
  49. P. Willeit, A. Zampetaki, K. Dudek et al., “Circulating microRNAs as novel biomarkers for platelet activation,” Circulation Research, vol. 112, no. 4, pp. 595–600, 2013. View at Google Scholar
  50. A. Zampetaki, P. Willeit, L. Tilling et al., “Prospective study on circulating microRNAs and risk of myocardial infarction,” Journal of the American College of Cardiology, vol. 60, no. 4, pp. 290–299, 2012. View at Google Scholar
  51. S. Grasedieck, A. Sorrentino, C. Langer et al., “Circulating microRNAs in hematological diseases: principles, challenges, and perspectives,” Blood, vol. 121, no. 25, pp. 4977–4984, 2013. View at Google Scholar