Antidiabetic Activity of Pterospermum acerifolium Flowers and Glucose Uptake Potential of Bioactive Fraction in L6 Muscle Cell Lines with Its HPLC Fingerprint
Table 1
Effect of ethyl acetate fraction and subfractions of flowers of Pterospermum acerifolium (L.) Willd on changes in blood glucose level during OGTT.
Treatment
Blood glucose level (mg/dL)
0th min
30th min
60th min
120th min
Normal control
75.2 ± 0.477
144.2 ± 0.477
139.2 ± 1.046
121.2 ± 1.600
Diabetic control
353 ± 11.8aaaa
442.8 ± 16.22aaaa
439.7 ± 18.97aaaa
398.2 ± 12.96aaaa
PAFEF1
234.6 ± 5.02
301 ± 5.373
278.8 ± 6.582
266.5 ± 7.602
PAFEF2
233 ± 16.8
292.2 ± 16.11
262.7 ± 15.95
249 ± 16.48
PAFE1-1
226 ± 7.44
278.8 ± 6.258
260.2 ± 8.845
246.5 ± 7.610
PAFE1-2
235 ± 13.5
285.7 ± 15.82
260.7 ± 15.68
249.7 ± 14.71
PAFE2-1
221 ± 6.11
275 ± 8.418
253.3 ± 7.032
236.5 ± 9.021
PAFE2-2
194 ± 7.77bb
247.7 ± 6.556bbb
221.3 ± 5.760bb
200 ± 7.554bb
PAFE3-1
269 ± 11.3aa
318.5 ± 15.64aa
313.3 ± 12.30aaa
309.3 ± 14.18aaa
PAFE3-2
264 ± 9.77aa
314.8 ± 9.365a
306 ± 10.17aa
295.8 ± 9.203aa
STD drug
176 ± 6.90bbb
225 ± 4.892bbbb
193 ± 4.235bbb
177.3 ± 8.773bbb
The results are expressed as mean ± standard error of the mean (SEM). Probability values of < 0.0001, aaa < 0.001, aa < 0.01, and a < 0.05 were compared with normal control. Probability values of bbbb < 0.0001, bbb < 0.001, bb < 0.01, and b < 0.05 were compared with disease control.