Synthesis and Evaluation of Tetramethylguanidinium-Polyethylenimine Polymers as Efficient Gene Delivery Vectors

Table 2

Size and zeta potential measurements of TP polymers and their pDNA complexes at w/w ratio of 3.3 in water and 10% FBS.

S. No.	Samples	Zeta potential (in mV) ± SD			Average particle size (in nm) ± SD
		Sample (in H2O); (+)	DNA complex (in H2O); (+)	DNA complex (in 10% FBS)	DNA complex (in H2O)	DNA complex; (in 10% FBS)
1	TP1	50.8 ± 2.5	43.2 ± 3.4	−7.9 ± 0.4	244.1 ± 21.7	48.3 ± 3.5
2	TP2	42.9 ± 3.4	38.3 ± 2.6	−9.1 ± 1.1	263.5 ± 26.5	65.6 ± 5.2
3	TP3	35.2 ± 2.1	22.8 ± 2.1	−9.9 ± 1.3	341.3 ± 30.4	79.6 ± 8.1
4	TP4	34.4 ± 3.2	20.6 ± 1.7	−12.4 ± 0.8	423.1 ± 35.8	90.9 ± 7.8
5	TP5	31.7 ± 2.8	16.0 ± 1.2	−18.0 ± 1.8	448.2 ± 42.4	130.0 ± 10.5
6	bPEI	40.2 ± 3.6	27.8 ± 2.3	−16.7 ± 2.1	282.2 ± 26.2	42.3 ± 7.5