Increased Release Time of Antibiotics from Bone Allografts through a Novel Biodegradable Coating

Table 3

The daily released amount of amoxicillin measured with either replacing the solvent daily or replenishing the solvent. There were significant differences in the 1st and 2nd day with the different methods.

Released drug (mg/day)	Amoxicillin; solvent replenishment	Amoxicillin; cumulative release
	Mean ± SEM	Mean ± SEM
Day 1**	0.260 ± 0.037	0.168 ± 0.030
Day 2***	0.202 ± 0.026	0.098 ± 0.005
Day 3	0.081 ± 0.015	0.085 ± 0.016
Day 4	0.049 ± 0.013	0.063 ± 0.009
Day 5	0.032 ± 0.012	0.042 ± 0.012
Day 6	0.007 ± 0.002	0.021 ± 0.015
Day 7	0.003	0.001 ± 0.001
Day 8	0.003	0.002

∗∗is the difference between the released drug on the first day with the two different methods, and *** is the difference between the released drug on the second day with the two different methods.