The Roles of CD73 in Cancer

Table 1

CD73 expression in different cancer cell lines.

Cancer type	Cell line	Expression	Reference
Glioblastoma Multiforme	T98G	Higher level of mRNA and protein than normal glial cell line SVGp12	[8]
Melanoma	C8161, PMW, SBCL2, SKMel28, SKMel30, KMel147, SKMel173, Mel224, WM266-4, M902-6	Higher mRNA expression than WM35 et al. because the absent of methylation	[9]
Melanoma	WM35, Mel501, Mel505, SKMel2, SKMel23, C81-61	Lower mRNA expression caused by the NT5E CpG island methylation	[9]
Melanoma	A375	High expression levels and activity	[10]
Mouse breast; cancer	4T1.2, E0771	Higher expression levels than nonmetastatic variant of 4T1.2	[11]
Ovarian cancer	SKOV3	SKOV3 human ovarian cancer cells highly expressed CD73	[12]
Breast cancer	MB-MDA-231, T-47D	T-47D with lower expression of CD73 and MB-MDA-231 with higher expression of CD73	[13]
Primary Medulloblastoma; Metastatic Medulloblastoma	Daoy, ONS76; D283	Daoy and ONS76 express higher levels of CD73 while D283 revealed poor expression of CD73	[14]
Bladder cancer	RT4, T24	Both cell lines expressed CD73	[15]