Bacteriostatic Antimicrobial Combination: Antagonistic Interaction between Epsilon-Viniferin and Vancomycin against Methicillin-Resistant Staphylococcus aureus

Table 3

Determination of FICI values and interaction effects of stilbenoid and antibiotic combinations against MRSA.

Strains	Agents	MIC (mg/mL)		FIC (mg/mL)		Outcome
		Alone	Combination	FIC	FICI
ATCC 33591	𝜀-Viniferin	0.05	0.00625	0.125
	Vancomycin	0.002	0.00025	0.125	0.25	Synergistic
	𝜀-Viniferin	0.05	0.00625	0.125
	Linezolid	0.0125	0.0125	1	1.12	Indifference
	Johorenol A	0.05	0.05	1
	Vancomycin	0.002	0.000125	0.062	1.06	Indifference
	Johorenol A	0.05	0.05	1
	Linezolid	0.0125	0.00025	0.02	1.02	Additive
HUKM strain	𝜀-Viniferin	0.1	0.01250	0.125
	Vancomycin	0.002	0.000125	0.0625	0.19	Synergistic
	𝜀-Viniferin	0.1	0.00625	0.0625
	Linezolid	0.0125	0.0125	1	1.06	Indifference
	Johorenol A	0.05	0.05	1
	Vancomycin	0.002	0.00025	0.125	1.12	Indifference
	Johorenol A	0.05	0.05	1
	Linezolid	0.0125	0.00025	0.02	1.02	Additive