Research Article
Subchronic Toxicity Study in Rats of Two New Ethyl-Carbamates with Ixodicidal Activity
Table 3
Weights of the organs relative to the body weights (%) of the female and male Wistar rats that were subchronically exposed to LQM 919 or LQM 996.
| Liver, kidney, brain, and spleen weights relative to body weight (%) | Treatment | Liver | Kidney | Brain | Spleen | Females | Males | Females | Males | Females | Males | Females | Males |
| LQM 919 (50 mg/kg/day) | 3.43 (±0.18)a | 3.22 (±0.22)a | 0.36 (±0.02)a | 0.35 (±0.04)a | 0.75 (±0.07)a | 0.49 (±0.04)a | 0.38(±0.08)b | 0.28(±0.04)b | LQM 919 (25 mg/kg/day) | 3.86 (±0.47)a | 3.08 (±0.03)a | 0.33 (±0.01)a | 0.33 (±0.01)a | 0.70 (±0.17)a | 0.41 (±0.14)a | 0.51(±0.17)b | 0.41(±0.14)b | LQM 919 (12.5 mg/kg/day) | 3.35 (±0.33)a | 3.54 (±0.37)a | 0.35 (±0.04)a | 0.33 (±0.01)a | 0.65 (±0.04)a | 0.52 (±0.10)a | 0.35(±0.04)a | 0.22(±0.01)a | LQM 919 (25 mg/kg/day) Sg | 3.83 (±0.01)a | 3.60 (±0.24)a | 0.34 (±0.04)a | 0.34 (±0.02)a | 0.67 (±0.05)a | 0.38 (±0.01)a | 0.26 (±0.00)a | 0.18 (±0.03)a |
| LQM 996 (50 mg/kg/day) | 3.96 (±0.34)a | 3.55 (±0.24)a | 0.33 (±0.02)a | 0.33 (±0.01)a | 0.71 (±0.08)a | 0.47 (±0.04)a | 0.47 (±0.06)b | 0.44 (±0.08)b | LQM 996 (25 mg/kg/day) | 3.90 (±0.53)a | 3.60 (±0.03)a | 0.35 (±0.02)a | 0.35 (±0.05)a | 0.72 (±0.09)a | 0.48 (±0.05)a | 0.55 (±0.07)b | 0.39 (±0.08)b | LQM 996 (12.5 mg/kg/day) | 3.69 (±0.39)a | 3.46 (±0.30)a | 0.33 (±0.03)a | 0.33 (±0.03)a | 0.69 (±0.10)a | 0.50 (±0.08)a | 0.37 (±0.04)a | 0.31 (±0.06)b | LQM 996 (25 mg/kg/day) Sg | 3.53 (±0.40)a | 3.51 (±0.06)a | 0.34 (±0.00)a | 0.33 (±0.03)a | 0.72 (±0.15)a | 0.38 (±0.03)a | 0.25 (±0.01)a | 0.24 (±0.04)a |
| Control group | 3.59 (±0.21)a | 3.25 (±0.17)a | 0.33 (±0.01)a | 0.32 (±0.02)a | 0.69 (±0.08)a | 0.46 (±0.03)a | 0.26 (±0.02)a | 0.19 (±0.03)a |
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Sg: satellite group. Different letters indicate statistical differences between means ().
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