Subchronic Toxicity Study in Rats of Two New Ethyl-Carbamates with Ixodicidal Activity
Table 5
Effects of subchronic exposure to LQM 996 on selected parameters in male and female Wistar rats.
Parameter
Group
Females
Males
Control (—)
12.5 mg/kg/day
25 mg/kg/day
25 mg/kg/day (Sg)
50 mg/kg/day
Control (—)
12.5 mg/kg/day
25 mg/kg/day
25 mg/kg/day (Sg)
50 mg/kg/day
AST (U/L)
238.2 (±78.13)
263.4 (±82.12)
192.3 (±84.08)
181.8 (±23.10)
207.5 (±96.51)
195.8 (±70.16)
265.6 (±26.8)
167.8 (±30.81)
196.9 (±60.23)
168.3 (±18.03)
ALT (U/L)
61.52 (±19.55)
90.14 (±84.82)
44.37 (±21.49)
83.43 (±17.10)
52.26 (±13.00)
60.64 (±32.21)
74.84 (±58.61)
38.33 (±12.79)
72.70 (±15.67)
63.04 (±15.46)
LDH (U/L)
924.2 (±285.6)
908.8 (±279.8)
506.0 (±241.0)
547.0 (±74.75)
609.0 (±249.0)
739.5 (±334.1)
942.4 (±310.5)
441.0 (±146.5)
694.0 (±387.2)
607.8 (±143.7)
GGT (U/L)
1.71 (±2.28)
—
1.29 (±1.99)
1.56 (±0.36)
1.62 (±1.57)
0.34 (±0.25)
2.24 (±3.14)
6.29 (±4.82)*
2.10 (±1.58)
6.59 (±5.35)*
CHE (U/L)
953.9 (±526.7)
1505 (±348.6)
984.6 (±210.9)
1754 (±838.4)
892.8 (±317.8)
344.3 (±111.1)
546.4 (±308.4)
385.0 (±71.40)
716.5 (±488.1)
528.0 (±94.73)
Creatinin (mg/dL)
0.44 (±0.20)
0.43 (±0.07)
0.44 (±0.02)
0.38 (±0.05)
0.49 (±0.10)
0.54 (±0.12)
0.50 (±0.12)
0.60 (±0.10)
0.52 (±0.09)
0.54 (±0.17)
Total protein (g/dL)
5.83 (±1.07)
6.92 (±1.23)
5.88 (±1.12)
6.98 (±0.06)
5.93 (±0.08)
5.52 (±0.76)
5.96 (±0.39)
5.95 (±0.37)
6.26 (±0.71)
6.38 (±0.72)
Albumin (g/dL)
2.36 (±1.05)
2.40 (±1.31)
1.83 (±1.51)
2.04 (±1.09)
1.87 (±1.04)
1.72 (±0.86)
2.18 (±0.72)
2.16 (±0.92)
2.40 (±0.20)
2.01 (±0.81)
Globulin (g/dL)
3.47 (±0.89)
4.52 (±1.53)
4.05 (±1.36)
4.94 (±1.12)
4.06 (±1.01)
3.80 (±0.27)
3.79 (±0.84)
3.79 (±0.55)
3.86 (±0.84)
4.38 (±1.43)
Reticulocytes (%)
4.21 (±0.35)
8.82 (±1.61)*
10.06 (±2.15)*
2.34 (±0.25)
9.92 (±3.42)*
3.93 (±0.77)
5.23 (±1.44)*
6.65 (±1.15)*
3.38 (±0.37)
6.60 (±0.97)*
Hematocrit (%)
36.62 (±2.92)
38.00 (±6.97)
34.4 (±9.52)
35.00 (±11.00)
36.80 (±8.49)
35.70 (±3.89)
44.25 (±3.20)*
37.30 (±6.41)
41.33 (±2.51)
43.60 (±4.72)*
A/G
0.74 (±0.39)
0.64 (±0.46)
0.56 (±0.63)
0.47 (±0.34)
0.53 (±0.37)
0.46 (±0.24)
0.62 (±0.31)
0.60 (±0.30)
0.65 (±0.21)
0.55 (±0.36)
AST: aspartate aminotransferase, ALT: alanine aminotransferase, LDH: lactate dehydrogenase, GGT: gamma-glutamyltransferase, CHE: cholinesterase, A/G: albumin and globulin, Sg: satellite group. Values are presented as the means ± the SDs. (significantly different from the unexposed group).
