Review Article

Neuroimaging to Investigate Multisystem Involvement and Provide Biomarkers in Amyotrophic Lateral Sclerosis

Figure 1

Evidence of hippocampal and basal ganglia involvement in amyotrophic lateral sclerosis. Comparative surface-based vertex analyses between healthy controls and C9orf72 hexanucleotide repeat negative ALS patients corrected for age and multiple comparisons reveal significant left hippocampal (a) and thalamic changes (b) (Courtesy of Peter Bede-Trinity College Dublin).
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(a)
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(b)