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BioMed Research International
Volume 2014, Article ID 470253, 8 pages
http://dx.doi.org/10.1155/2014/470253
Research Article

Lung Cancer Stem Cell Lose Their Stemness Default State after Exposure to Microgravity

1Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy
2Department of Surgery “P.Valdoni,” Sapienza University, 00161 Rome, Italy
3Department of Clinical and Molecular Medicine, Sapienza University, 00161 Rome, Italy
4IRCCS Istituto Nazionale Tumori, Fondazione G. Pascale, 80131 Napoli, Italy
5Azienda Ospedaliera S. Andrea, 00189 Rome, Italy
6Department of Experimental Medicine, Sapienza University, 00161 Rome, Italy

Received 13 May 2014; Revised 14 July 2014; Accepted 8 August 2014; Published 7 September 2014

Academic Editor: Anton M. Jetten

Copyright © 2014 Maria Elena Pisanu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [17 citations]

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  • Prasanna Vidyasekar, Pavithra Shyamsunder, Rajpranap Arun, Rajalakshmi Santhakumar, Nand Kishore Kapadia, Ravi Kumar, and Rama Shanker Verma, “Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Netwo,” Plos One, vol. 10, no. 8, 2015. View at Publisher · View at Google Scholar
  • Tania I. Fuentes, Nancy Appleby, Michael Raya, Leonard Bailey, Nahidh Hasaniya, Louis Stodieck, and Mary Kearns-Jonker, “Simulated Microgravity Exerts an Age-Dependent Effect on the Differentiation of Cardiovascular Progenitors Isolated from the Human Heart,” Plos One, vol. 10, no. 7, 2015. View at Publisher · View at Google Scholar
  • Brook T. Chernet, Chris Fields, and Michael Levin, “Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos,” Frontiers in Physiology, vol. 5, 2015. View at Publisher · View at Google Scholar
  • Zofia F. Bielecka, Kamila Maliszewska-Olejniczak, Ilan J. Safir, Cezary Szczylik, and Anna M. Czarnecka, “Three-dimensional cell culture model utilization in cancer stem cell research,” Biological Reviews, 2016. View at Publisher · View at Google Scholar
  • Mariano Bizzarri, and Alessandra Cucina, “SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms,” Acta Biotheoretica, 2016. View at Publisher · View at Google Scholar
  • Johann Bauer, Markus Bussen, Petra Wise, Markus Wehland, Sabine Schneider, and Daniela Grimm, “Searching the literature for proteins facilitates the identification of biological processes, if advanced methods of analysis are linked: a case study on microgravity-caused changes in cells,” Expert Review of Proteomics, pp. 1–9, 2016. View at Publisher · View at Google Scholar
  • Sascha Kopp, Lasse Slumstrup, Thomas J. Corydon, Jayashree Sahana, Ganna Aleshcheva, Tawhidul Islam, Nils E. Magnusson, Markus Wehland, Johann Bauer, Manfred Infanger, and Daniela Grimm, “Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine,” Scientific Reports, vol. 6, pp. 26887, 2016. View at Publisher · View at Google Scholar
  • Masakazu Sato, Kei Kawana, Katsuyu Kiadachi, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Takahashi, Satoko Kojima, Aki Yamashita, Kensuke Tomio, Takeshi Nagamatsu, Osamu Wada-Hiraike, Katsutoshi Oda, Yutaka Osuga, and Tomoyuki Fuji, “Decreased expression of the plasminogen activator inhibitor type 1 is involved in degradation of extracellular matrix surrounding cervical cancer stem,” International Journal Of Oncology, vol. 48, no. 2, pp. 829–835, 2016. View at Publisher · View at Google Scholar
  • Flavia Biamonte, Maria Elena Pisanu, Maria Concetta Faniello, Žiga Jakopin, Emilia Dora Giovannone, Rita Mancini, Nadia Lobello, Giovanni Cuda, Francesco Costanzo, Emanuela Chiarella, and Gennaro Ciliberto, “Ferritin heavy chain is a negative regulator of ovarian cancer stem cell expansion and epithelial to mesenchymal transition,” Oncotarget, vol. 7, no. 38, pp. 62019–62033, 2016. View at Publisher · View at Google Scholar
  • Mariano Bizzarri, Alessandra Cucina, and Sara Proietti, “Tumor reversion: Mesenchymal-epithelial transition as a critical step in managing the tumor-microenvironment cross-talk,” Current Pharmaceutical Design, vol. 23, no. 32, pp. 4705–4715, 2017. View at Publisher · View at Google Scholar
  • Günter Ruyters, Christian Betzel, Daniela Grimm, Marcus Krüger, Johann Bauer, and Daniela Grimm, “Cancer Research in Space,” Biotechnology in Space, pp. 87–106, 2017. View at Publisher · View at Google Scholar
  • Maria Elena Pisanu, Alessia Noto, Claudia De Vitis, Stefania Morrone, Giosuè Scognamiglio, Gerardo Botti, Federico Venuta, Daniele Diso, Ziga Jakopin, Padula Fabrizio, Alberto Ricci, Salvatore Mariotta, Maria Rosaria Giovagnoli, Enrico Giarnieri, Ivano Amelio, Massimiliano Agostini, Gerry Melino, Gennaro Ciliberto, and Rita Mancini, “Blockade of Stearoyl-CoA-Desaturase 1 activity reverts resistance to Cisplatin in lung cancer stem cells,” Cancer Letters, 2017. View at Publisher · View at Google Scholar
  • Junji Morokuma, Fallon Durant, Katherine B. Williams, Joshua M. Finkelstein, Douglas J. Blackiston, Twyman Clements, David W. Reed, Michael Roberts, Mahendra Jain, Kris Kimel, Sunia A. Trauger, Benjamin E. Wolfe, and Michael Levin, “Planarian regeneration in space: Persistent anatomical, behavioral, and bacteriological changes induced by space travel,” Regeneration, vol. 4, no. 2, pp. 85–102, 2017. View at Publisher · View at Google Scholar
  • Qing Luo, Zhe Chen, Lin Yuan, and Guanbin Song, “Microgravity directs stem cell differentiation,” Histology and Histopathology, vol. 32, no. 2, pp. 99–106, 2017. View at Publisher · View at Google Scholar
  • Mariano Bizzarri, Maria Grazia Masiello, Alessandro Giuliani, and Alessandra Cucina, “Gravity Constraints Drive Biological Systems Toward Specific Organization Patterns,” BioEssays, pp. 1700138, 2017. View at Publisher · View at Google Scholar
  • Aviseka Acharya, Sonja Brungs, Magit Henry, Tamara Rotshteyn, Nirmala Singh Yaduvanshi, Lucia Wegener, Simon Jentzsch, Juergen Hescheler, Ruth Hemmersbach, Helene Boeuf, and Agapios Sachinidis, “Modulation of differentiation processes in murine embryonic stem cells exposed to parabolic flight-induced acute hypergravity and microgravity,” Stem Cells and Development, 2018. View at Publisher · View at Google Scholar
  • Maria Grazia Masiello, Roberto Verna, Alessandra Cucina, and Mariano Bizzarri, “Physical constraints in cell fate specification. A case in point: Microgravity and phenotypes differentiation,” Progress in Biophysics and Molecular Biology, 2018. View at Publisher · View at Google Scholar